SubtiBank SubtiBank
dtpT
Save the date! 20th International Conference on Bacilli and Gram-Positive Bacteria. Washington, D.C. July 23-26, 2019.

dtpT

proton-dependent di- and tripeptide transporter
locus
BSU_03670
pI
9.92
mw
53.11 kDa
protein length
492 aa Sequence Blast
gene length
1479 bp Sequence Blast
function
uptake of di- and tripeptides
product
peptide transporter
essential
no
synonyms
yclF

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.4|Transporters/ other] → [category|SW 1.2.4.2|Peptide transporter]
  • [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.3|Utilization of nitrogen sources other than amino acids] → [category|SW 2.3.3.4|Utilization of peptides]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]
  • Gene

    Coordinates
    416,235 417,713

    The protein

    Protein family

  • PTR2/POT transporter (TC 2.A.17) family (single member, according to UniProt)
  • Structure

  • [PDB|4IKV], the protein from ''Geobacillus kaustophilus'' (65% identity, 87% similarity), [Pubmed|23798427]
  • [SW|Localization]

  • cell membrane (according to UniProt)
  • Expression and Regulation

    Operons

    genes
    [gene|819D6C5489F1F3FF63B69162EFB6581A1366F45E|dtpT]
    description
    [Pubmed|22383849]

    sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|25966844], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]
  • regulatory mechanism

  • [protein|F7FD94CE7AB290FBFD3A9B88F204961668F9B42C|ScoC]: repression, [Pubmed|25966844,11717292], in [regulon|F7FD94CE7AB290FBFD3A9B88F204961668F9B42C|ScoC regulon]
  • [protein|857EF1AC54DEA0690C01B7F8CEFFD16312C58F20|TnrA]: activation, in [regulon|857EF1AC54DEA0690C01B7F8CEFFD16312C58F20|TnrA regulon]
  • regulation

  • repressed during exponential growth ([protein|F7FD94CE7AB290FBFD3A9B88F204961668F9B42C|ScoC]) [Pubmed|25966844,11717292]
  • view in new tab

    additional information

  • the mRNA is cleaved by [protein|BAB297D18F94FFA67B8D12A684AB4D1BCDFB4981|RNase III] [PubMed|26883633]
  • Biological materials

    Mutant

  • BKE03670 ([gene|819D6C5489F1F3FF63B69162EFB6581A1366F45E|dtpT]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE03670 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTCAGCCAAACCCTTTC, downstream forward: _UP4_TAATCAGAAACAGCCCGCGG
  • BKK03670 ([gene|819D6C5489F1F3FF63B69162EFB6581A1366F45E|dtpT]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK03670 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTCAGCCAAACCCTTTC, downstream forward: _UP4_TAATCAGAAACAGCCCGCGG
  • References

  • 11717292,8458848,23798427,25966844,25755103,26883633