branched-chain amino acid aminotransferase
function
biosynthesis of branched-chain amino acids
product
branched-chain amino acid aminotransferase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.12|Biosynthesis/ acquisition of branched-chain amino acids][SW|Categories] containing this gene/protein
[SW|biosynthesis/ acquisition of amino acids], [SW|most abundant proteins]This gene is a member of the following [SW|regulons]
[SW|CodY regulon]Gene
Coordinates on the chromosome (coding sequence)
3,957,391 -> 3,958,482
The protein
Catalyzed reaction/ biological activity
L-leucine 2-oxoglutarate = 4-methyl-2-oxopentanoate L-glutamate (according to Swiss-Prot) Protein family
class-IV pyridoxal-phosphate-dependent aminotransferase family (according to Swiss-Prot)Paralogous protein(s)
[protein|search|YbgE]Modification
S-cysteinylation after diamide stress (C104) [Pubmed|17611193]Structure
[PDB|3HT5] (from '' Mycobacterium tuberculosis'', 42% identity, 58% similarity) [Pubmed|19923721]Expression and Regulation
Operon
''ywaA'' [Pubmed|9353933]Regulation
repressed during growth in the presence of branched chain amino acids ([protein|search|CodY]) [Pubmed|24163341]Regulatory mechanism
[protein|search|CodY]: transcription repression [Pubmed|24163341]Additional information
belongs to the 100 [SW|most abundant proteins] [PubMed|15378759]Biological materials
Mutant
a ''ywaA::spc'' mutant and a ''[protein|search|bcd] [protein|search|ybgE] [protein|search|ywaA]'' triple mutant are available in [SW|Linc Sonenshein]'s labReferences
12670965,17611193,24163341,15378759 
