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sdhC [Tue Dec 13 2016 11:16:35 GMT+0100 (CET)]
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sdhC [Tue Dec 13 2016 11:16:35 GMT+0100 (CET)]

succinate dehydrogenase (cytochrome b558 subunit)
22.00 kDa
TCA cycle
succinate dehydrogenase (cytochrome b558 subunit)

Genomic Context



  • [category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.1|Carbon core metabolism] → [category|SW|TCA cycle]
  • [category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.2|Biofilm formation] → [category|SW|Other proteins required for biofilm formation]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]
  • [SW|Categories] containing this gene/protein

  • [SW|carbon core metabolism], [SW|membrane proteins]
  • This gene is a member of the following [SW|regulons]

  • [SW|FsrA regulon]
  • Gene

    Coordinates on the chromosome (coding sequence)
    2,908,129 -> 2,908,737

    Phenotypes of a mutant

  • defective in the the ability to support the growth of ''Synechococcus leopoliensis'' CCAP1405/1 on agar media [Pubmed|25875741]
  • The protein

    Protein family

  • cytochrome b558 family (according to Swiss-Prot)
  • [SW|Cofactors]

  • Fe
  • Effectors of protein activity

  • Inhibited by 2-(n-Heptyl)-4-hydroxy-quinoline N-oxide [Pubmed|3910107]
  • Activated by Cytochrome b558 [Pubmed|6799760]
  • Structure

  • [PDB|1NEK] (''E. coli'')
  • [SW|Localization]

  • membrane protein [Pubmed|18763711]
  • [SW|Interactions]

  • [protein|search|SdhB]-[protein|search|SdhC] (as part of the [protein|search|SdhC]-[protein|search|SdhB]-[protein|search|SdhA] complex)
  • part of a [SW|respiratory supercomplex] [Pubmed|23880299]
  • Additional information

  • This enzyme is a trimer membrane-bound [Pubmed|3910107] [Pubmed|6799760]
  • One subunit is bound to citochrome b558, and this subunit is the one bound to the cytosolic side of the membrane [Pubmed|3910107] [Pubmed|6799760]
  • Another subunit is the flavoprotein one, required for FAD usage [Pubmed|3910107] [Pubmed|6799760]
  • The other subunit has an iron-sulphur domain necessary for the catalytic activity [Pubmed|3910107] [Pubmed|6799760]
  • extensive information on the structure and enzymatic properties of succinate dehydrogenase can be found at [ Proteopedia]
  • Expression and Regulation


  • ''[protein|search|sdhC]''-''[protein|search|sdhA]''-''[protein|search|sdhB]'' [Pubmed|3036777]
  • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|2495271]
  • Regulation

  • SdhC is less expressed under conditions of extreme iron starvation ([protein|search|FsrA]) [Pubmed|18697947]
  • part of the iron sparing response ([protein|search|FsrA]) [Pubmed|22389480]
  • Regulatory mechanism

  • [protein|search|FsrA]: translation inhibition [Pubmed|22389480]
  • Biological materials


  • GP743 (''[protein|search|sdhC]-[protein|search|sdhA]'', cat), available in [SW|Jörg Stülke]'s lab
  • GP792 (''[protein|search|sdhC]-[protein|search|sdhA]-[protein|search|sdhB]''::''phleo''), available in [SW|Jörg Stülke]'s lab
  • GP2342 (''[protein|search|sdhC]-[protein|search|sdhA]-[protein|search|sdhB]''::''kan''), Cre-recombinase is integrated in ''[protein|search|sacA]'', available in [SW|Jörg Stülke]'s lab
  • GP2343 (''[protein|search|sdhC]-[protein|search|sdhA]-[protein|search|sdhB]''::''lox72''), Cre-recombinase is integrated in ''[protein|search|sacA]'', available in [SW|Jörg Stülke]'s lab
  • two-hybrid system

  • ''B. pertussis'' adenylate cyclase-based bacterial two hybrid system ([SW|BACTH]), available in [SW|Jörg Stülke]'s lab
  • References


  • 11803018
  • Original publications

  • 6401289,1707123,2120540,7669765,18697947,1324713,3036777,2495271,2176107,3117551,10913269,18763711,12560550,18697947,3910107,6799760,21641999,22389480,23880299,25875741