SubtiBank SubtiBank
folC

folC

folyl-polyglutamate synthetase
locus
BSU_28080
pI
5.81
mw
48.00 kDa
protein length
430 aa Sequence Blast
gene length
1293 bp Sequence Blast
function
biosynthesis of folate
product
folyl-polyglutamate synthetase
essential
yes
ec
6.3.2.17
synonyms

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.5|Biosynthesis of folate]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • Gene

    Coordinates
    2,865,312 2,866,604

    Phenotypes of a mutant

  • essential [Pubmed|28189581]
  • The protein

    Catalyzed reaction/ biological activity

  • 7,8-dihydropteroate + ATP + L-glutamate --> 7,8-dihydrofolate + ADP + H+ + phosphate (according to UniProt)
  • (6S)-5,6,7,8-tetrahydrofolyl-(γ-L-Glu)n + ATP + L-glutamate --> (6S)-5,6,7,8-tetrahydrofolyl-(γ-L-Glu)n+1 + ADP + H+ + phosphate (according to UniProt)
  • Protein family

  • Folylpolyglutamate synthase family (single member, according to UniProt)
  • Structure

  • [PDB|1FGS] (from ''Lactobacillus casei'', 32% identity, 51% similarity) [Pubmed|9618466]
  • [SW|Localization]

  • cytoplasm (according to UniProt)
  • Expression and Regulation

    Operons

    genes
    [gene|3E84B3AC08D0B314286CEF38534BD81B568F3E0E|valS]-[gene|80502F76F076C08CCE702F25095C06D14CD8154A|folC]
    description
    [Pubmed|9098041]

    sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|9098041], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]
  • regulatory mechanism

  • [regulon|T-box|T-box]: transcription termination/antitermination, via [SW|riboswitch], in [regulon|T-box|T-box]
  • regulation

  • induced by valine limitation ([SW|T-box]) [Pubmed|9098041,19258532]
  • the [SW|T-box] RNA is degraded by [protein|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y] [pubmed|29794222]
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    References

    Reviews

  • 19258532
  • Original Publications

  • 9098041,28189581