rplT

ribosomal protein

Locus: BSU_28850

Isoelectric point: 11.90

Molecular weight: 13.50 kDa

Protein length: 119 aa

Gene length: 360 bp

Function: translation

Product: ribosomal protein L20

Essential: yes

Synonyms

Genomic Context

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Categories containing this gene/protein

• Information processing → Protein synthesis, modification and degradation → Translation → Ribosomal proteins
• Information processing → Regulation of gene expression → RNA binding regulators
• Groups of genes → Essential genes

Gene

Coordinates: 2,952,224 2,952,583

Phenotypes of a mutant

• essential PubMed

The protein

Catalyzed reaction/ biological activity

• excess RplT binds the untranslated region of the infC-rpmI-rplT-ysdA operon mRNA to terminate transcription PubMed

Protein family

• bacterial ribosomal protein bL20 family (single member, according to UniProt)

Structure

• 3J9W (the ribosome) PubMed

Localization

• cytosolic large ribosomal subunit (according to UniProt)

Expression and Regulation

Operons

• Genes: infC-rpmI-rplT-ysdA
  Description: PubMed

  Regulatory mechanism

  • stringent response: negative regulation, in stringent response
  • RplT: termination, via binding to a RNA switch in the infC leader region causes transcription termination, in RplT regulon

  Regulation

  • RelA dependent downregulation (Class I) during stringent response PubMed

  Additional information

  • autorepression of infC-rpmI-rplT-ysdA expression upon binding of excess RplT to the untranslated region of the mRNA PubMed
  • expression of IF3 is uncoupled from that of L35 and L20 by RNase Y-dependent mRNA processing PubMed
  • the RNA switch RNA is degraded by RNase Y PubMed

References

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