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argD [2019-05-09 17:41:06]
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argD [2019-05-09 17:41:06]

acetylornithine transaminase
locus
BSU11220
pI
5.93
mw
40.74 kDa
protein length
385 aa Sequence Blast
gene length
1155 bp Sequence Blast
function
biosynthesis of arginine
product
acetylornithine transaminase
essential
no
ec
2.6.1.11
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.4|Biosynthesis/ acquisition of arginine]

    • Gene

    Coordinates
    1,198,099 → 1,199,256

    The protein

    Catalyzed reaction/ biological activity

  • N(2)-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate (according to Swiss-Prot)

    • Protein family

  • ArgD subfamily (according to Swiss-Prot)

    • [SW|Cofactors]

  • PLP (according to UniProt)

    • Structure

  • [PDB|2EH6] (from Aquifex aeolicus, 45% identity)

    • [SW|Localization]

  • cytoplasm (according to Swiss-Prot)

    • Expression and Regulation

    Operons

    genes
    [gene|62678D45FA1CB1B6AB801FB9F574DDE10DEE068D|argC]-[gene|0FF858E44B3C557EE2C8B3749A458F152E1C535C|argJ]-[gene|8321DF6EE5B84CC9A4A5DF670E8611F4D61EBC7E|argB]-[gene|7FA5502FE82D55EC176F68B74B24293EC9B7D4D7|argD]-[gene|4202EAE5D0B2A718382092423DD99E35FDE81218|carA]-[gene|7E6386F1949A6F46E4332BAB8F803742EB076AF0|carB]-[gene|11E7D77EF9439F817C10BF5D9671C5AE66AF06DC|argF]
    description
    [Pubmed|7511775]

    sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|7511775], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]

    • regulatory mechanism

  • [protein|62F8E0D6BC9DA6390256FA8FB684EA5C9C722AE4|AhrC]: repression, [Pubmed|1312212], in [regulon|62F8E0D6BC9DA6390256FA8FB684EA5C9C722AE4|AhrC regulon]
  • [protein|90ACE0DECA58D3C1A55E135120F7A0C1C920571C|CodY]: repression, [Pubmed|24843172], in [regulon|90ACE0DECA58D3C1A55E135120F7A0C1C920571C|CodY regulon]
  • [protein|F4097349A563503468A2A14F062AEAC532C7917A|YlxR]: regulation, [pubmed|30355672], in [regulon|F4097349A563503468A2A14F062AEAC532C7917A|YlxR regulon]

    • regulation

  • repressed by arginine ([protein|62F8E0D6BC9DA6390256FA8FB684EA5C9C722AE4|AhrC]) [Pubmed|1312212]
  • induced in the absence of [protein|F4097349A563503468A2A14F062AEAC532C7917A|YlxR] [pubmed|30355672]
    • view in new tab

    Biological materials

    Mutant

  • BKE11220 (Δ[gene|7FA5502FE82D55EC176F68B74B24293EC9B7D4D7|argD]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE11220 BGSC], [Pubmed|28189581], upstream reverse: _UP1_GCTCATGAAACAGCCTCCTT, downstream forward: _UP4_TGATTTTTTTTCGATATAAA
  • BKK11220 (Δ[gene|7FA5502FE82D55EC176F68B74B24293EC9B7D4D7|argD]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK11220 BGSC], [Pubmed|28189581], upstream reverse: _UP1_GCTCATGAAACAGCCTCCTT, downstream forward: _UP4_TGATTTTTTTTCGATATAAA

    • References

  • 6096675,24843172,12107147,1312212,7511775