Holliday junction DNA helicase, part of the RuvA-RuvB branch migration translocase
function
DNA repair/ recombination
product
Holliday junction DNA helicase
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.5|DNA repair/ recombination][category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.5|DNA repair/ recombination] → [category|SW 3.1.5.4|Double strand breaks repair][SW|Categories] containing this gene/protein
[SW|DNA repair/ recombination]This gene is a member of the following [SW|regulons]
[SW|LexA regulon]Gene
Phenotypes of a mutant
the inactivations of ''[protein|search|recU]'' and ''[protein|search|ruvA]-[protein|search|ruvB]'' are synthetically lethal [Pubmed|24770420]The protein
Catalyzed reaction/ biological activity
inhibits resolution of Holliday junctions by [protein|search|RecU]-[protein|search|RuvB] [Pubmed|24770420]Protein family
ruvA family (according to Swiss-Prot)[SW|Interactions]
[protein|search|RuvA]-[protein|search|RuvB]Expression and Regulation
Operon
''[protein|search|ruvA]-[protein|search|ruvB]'' [Pubmed|16267290]Regulation
induced upon DNA damage ([protein|search|LexA]) [Pubmed|16267290]Regulatory mechanism
[protein|search|LexA]: transcription repression [Pubmed|16267290]Biological materials
Mutant
1A896 (no resistance), [Pubmed|16020779], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A896&Search=1A896 BGSC]References
Reviews
Original publications
16267290,24770420,16020779 
