SubtiBank SubtiBank
ruvA [Mon Aug 31 2015 13:56:01 GMT+0200 (CEST)]
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ruvA [Mon Aug 31 2015 13:56:01 GMT+0200 (CEST)]

Holliday junction DNA helicase, part of the RuvA-RuvB branch migration translocase
locus
BSU27740
pI
5.38
mw
22.00 kDa
function
DNA repair/ recombination
product
Holliday junction DNA helicase
essential
no
synonyms

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.5|DNA repair/ recombination]
  • [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.5|DNA repair/ recombination] → [category|SW 3.1.5.4|Double strand breaks repair]
  • [SW|Categories] containing this gene/protein

  • [SW|DNA repair/ recombination]
  • This gene is a member of the following [SW|regulons]

  • [SW|LexA regulon]
  • Gene

    Phenotypes of a mutant

  • the inactivations of ''[protein|search|recU]'' and ''[protein|search|ruvA]-[protein|search|ruvB]'' are synthetically lethal [Pubmed|24770420]
  • The protein

    Catalyzed reaction/ biological activity

  • inhibits resolution of Holliday junctions by [protein|search|RecU]-[protein|search|RuvB] [Pubmed|24770420]
  • Protein family

  • ruvA family (according to Swiss-Prot)
  • [SW|Interactions]

  • [protein|search|RuvA]-[protein|search|RuvB]
  • Expression and Regulation

    Operon

  • ''[protein|search|ruvA]-[protein|search|ruvB]'' [Pubmed|16267290]
  • Regulation

  • induced upon DNA damage ([protein|search|LexA]) [Pubmed|16267290]
  • Regulatory mechanism

  • [protein|search|LexA]: transcription repression [Pubmed|16267290]
  • Biological materials

    Mutant

  • 1A896 (no resistance), [Pubmed|16020779], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A896&Search=1A896 BGSC]
  • References

    Reviews

  • 22933559,9442895
  • Original publications

  • 16267290,24770420,16020779