SubtiBank SubtiBank
pncB
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pncB

nicotinate phosphoribosyltransferase
locus
BSU31750
pI
5.09
mw
56.01 kDa
protein length
490 aa Sequence Blast
gene length
1470 bp Sequence Blast
function
NAD salvage
product
nicotinate phosphoribosyltransferase
essential
yes
ec
2.4.2.11
synonyms
yueK

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.11|Biosynthesis of NAD(P)]
  • [category|SW 2|Metabolism] → [category|SW 2.7|Detoxification reactions]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • Gene

    Coordinates
    3,259,403 → 3,260,875

    Phenotypes of a mutant

  • essential [Pubmed|12682299]
  • The protein

    Catalyzed reaction/ biological activity

  • Nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate (according to Swiss-Prot)
  • Protein family

  • NAPRTase family (according to Swiss-Prot)
  • Structure

  • [PDB|2F7F] (from ''Enterococcus faecalis'', 61% identity)
  • Expression and Regulation

    Operons

    genes
    [gene|26430DCCEC263E7D03A3BBA4E7D636A250C3208B|pncA]-[gene|7CA7ADDBDDE46B0E6522704FD19C0BCF6FA9E058|pncB]
    description
    [Pubmed|22383849]
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    Biological materials

    Mutant

  • MGNA-B562 (yueK::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1561 NBRP B. subtilis, Japan]
  • References

  • 16199587,9274030