mnaA

UDP-N-acetylglucosamine 2-epimerase

locus: BSU_35660

pI: 5.47

mw: 42.48 kDa

protein length: 380 aa

gene length: 1143 bp

function: biosynthesis of teichoic acid

product: UDP-N-acetylglucosamine 2-epimerase

essential: yes

ec: 5.1.3.14

synonyms: yvyH

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.1|Cell wall synthesis] → [category|SW 1.1.1.4|Biosynthesis of teichoic acid]
• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.1|Biosynthesis of cell wall components] → [category|SW 2.6.1.3|Biosynthesis of teichoic acid]
• [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

Gene

Coordinates: 3,664,241 3,665,383

Phenotypes of a mutant

• essential [Pubmed|12682299]

The protein

Catalyzed reaction/ biological activity

• UDP-N-acetyl-α-D-glucosamine --> UDP-N-acetyl-α-D-mannosamine (according to UniProt)

Protein family

• UDP-N-acetylglucosamine 2-epimerase family (single member, according to UniProt)

Structure

• [PDB|1O6C] [Pubmed|16021622]

[SW|Localization]

• cytoplasm (according to Swiss-Prot)

Expression and Regulation

Operons

• genes: [gene|7BEAEDC0BE19F490B597BB0A6AEAE006FFBDC1D1|mnaA]
  description: [Pubmed|22383849]

Biological materials

Mutant

• MGNA-B651 (yvyH::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1650 NBRP B. subtilis, Japan]

References

Reviews

• 24024634

Original publications

• 12107153,16021622,24470206