SubtiBank SubtiBank
ohrR [Tue Dec 13 2016 11:16:32 GMT+0100 (CET)]
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ohrR [Tue Dec 13 2016 11:16:32 GMT+0100 (CET)]

transcription repressor of the ohrA gene
locus
BSU13150
pI
6.36
mw
16.00 kDa
function
regulation of ohrA expression
in response to organic peroxides
product
transcription repressor (MarR family)
essential
no
synonyms
ykmA

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.8|Resistance against oxidative and electrophile stress]
  • [SW|Categories] containing this gene/protein

  • [SW|transcription factors and their control], [SW|resistance against oxidative and electrophile stress]
  • Gene

    Coordinates on the chromosome (coding sequence)
    1,381,434 -> 1,381,877

    The protein

    Protein family

  • [SW|MarR family]
  • Modification

  • senses organic peroxides and NaOCl, released from DNA upon oxidation of an active site cysteine
  • S-bacillithiolated by NaOCl and CHP stress on Cys-15, this results in release from the'' [protein|search|ohrA]'' promoter [Pubmed|21749987]
  • Structure

  • [PDB|1Z91] (reduced form), [PDB|1Z9C] (complex with ''[protein|search|ohrA]'' promoter)
  • [SW|Localization]

  • cytoplasm (according to Swiss-Prot)
  • [SW|Interactions]

  • forms dimers
  • [protein|search|BrxA]-[protein|search|OhrR], to de-bacillithiolate S-bacillithiolated [protein|search|OhrR] [Pubmed|24313874]
  • [protein|search|BrxB]-[protein|search|OhrR], to de-bacillithiolate S-bacillithiolated [protein|search|OhrR] [Pubmed|24313874]
  • Expression and Regulation

    Operon

  • ''ohrR'' [Pubmed|9696771]
  • [SW|Sigma factor]

  • [protein|search|SigA]
  • Labs working on this gene/protein

  • [SW|John Helmann], Cornell University, USA [http://www.micro.cornell.edu/research/labs/helmann-lab/index.cfm Homepage]
  • [SW|Richard Brennan], Houston, Texas, USA [http://www.mdanderson.org/departments/biochem/display.cfm?id=556ef368-6c81-4043-b74f350d41dd06cb&method=displayfull&pn=a8427ebd-d0ff-11d4-80fd00508b603a14 Homepage]
  • References

    Reviews

  • 22797754,20626317,19575568,20094649,25852656
  • Original Publications

  • 21749987,16209951,18487332,17660290,17502599,12486061,11418552,18586944,11983871,18363800,19129220,9696771,21749987,22797754,24313874