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ftsL [2017-07-05 14:33:02]
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ftsL [2017-07-05 14:33:02]

cell-division protein (septum formation), controls together with EzrA dynamics of the FtsZ ring
locus
BSU15150
pI
10.08
mw
12.93 kDa
protein length
117 aa Sequence Blast
gene length
351 bp Sequence Blast
function
septum formation
product
cell-division protein
essential
yes
synonyms
ylxB, yllD

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.8|Cell division] → [category|SW 1.1.8.2|Other genes]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]
  • Gene

    Coordinates
    1,581,597 → 1,581,950

    Phenotypes of a mutant

  • essential [Pubmed|12682299]
  • The protein

    Protein family

  • ftsL family (according to Swiss-Prot)
  • Effectors of protein activity

  • degraded by [protein|CB50289535EA537F63BADD459BD11AA7759A6658|RasP], stabilized against [protein|CB50289535EA537F63BADD459BD11AA7759A6658|RasP] cleavage by [protein|FE0E60B875E72AEF5174A89C7AE5556FF59B19D5|DivIC] [Pubmed|20644139]
  • [SW|Localization]

  • cell membrane (according to Swiss-Prot)
  • localizes to the division site, this depends on [protein|8AB7D225DBEE6BD695A4A8A2384D2C029B571C57|FtsW] [Pubmed|27895631]
  • Expression and Regulation

    Operons

    genes
    [gene|A7131ACFA0CF5C222237C76E502D4AAD1F9BA3E4|mraZ]-[gene|1F894D6895CE13AA006CFE13A702E46C568F6E79|mraW]-[gene|79712F4CF884A660C71B45B3397AEFA5C0AFA683|ftsL]-[gene|EBEFF9E0A524DCDA19382E5401B923B805E4C559|pbpB]
    description
    [Pubmed|8636036,8244929]

    regulation

  • constitutively expressed [Pubmed|15758244]
  • view in new tab

    Biological materials

    Mutant

  • MGNA-B127 (ftsL::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1126 NBRP B. subtilis, Japan]
  • FLAG-tag construct

  • GP2004 ''ftsL-3xFLAG ermC'' (based on [SW|pGP1087]), available in [SW|Jörg Stülke]'s lab
  • References

    Reviews

  • 20836086
  • Original Publications

  • 9720875,10792716,16936019,16549676,17020588,8636036,10986263,11994149,10844672,19429628,20644139,21219466,23701187,2087076527895631