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htrB [Tue Dec 13 2016 11:16:36 GMT+0100 (CET)]
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htrB [Tue Dec 13 2016 11:16:36 GMT+0100 (CET)]

membrane-anchored protein quality control protease, serine protease, response to secretion and heat stresses
locus
BSU33000
pI
4.00
mw
48.00 kDa
function
protein quality control
product
serine protease
essential
no
ec
3.4.21.107
synonyms
yvtA, yvtB

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.7|Proteolysis] → [category|SW 3.3.7.1|Protein quality control]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.4|Heat shock proteins]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]
  • [SW|Categories] containing this gene/protein

  • [SW|proteolysis], [SW|heat shock proteins], [SW|membrane proteins]
  • This gene is a member of the following [SW|regulons]

  • [SW|CssR regulon]
  • Gene

    Coordinates on the chromosome (coding sequence)
    3,384,070 -> 3,385,446

    The protein

    Protein family

  • peptidase S1B family (according to Swiss-Prot)
  • Structure

  • [PDB|3QO6] (from ''Arabidopsis thaliana'', 38% identity) [Pubmed|21532594]
  • [SW|Localization]

  • cell membrane (according to Swiss-Prot)
  • randomly distributed in foci throughout the cell surface [Pubmed|22307758]
  • Expression and Regulation

    Operon

  • ''htrB'' (according to [http://dbtbs.hgc.jp/COG/prom/yvtA.html DBTBS])
  • Regulation

  • expressed under conditions of secretion stress ([protein|search|CssR]) [Pubmed|12270824]
  • induced by rhamnolipids [Pubmed|22092710]
  • Regulatory mechanism

  • [protein|search|CssR]: transcription activation [Pubmed|12270824]
  • Additional information

  • [protein|search|HtrB] is subject to degradation by [protein|search|WprA] and other extracellular proteases [PubMed|24362423]
  • References

    Reviews

  • 22688815,21326199,25212246
  • Original publications

  • 17600057,22307758,12270824,22092710,24362423,24115457,11133960,21532594