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dltA [Wed Feb 24 2016 15:14:22 GMT+0100 (CET)]
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dltA [Wed Feb 24 2016 15:14:22 GMT+0100 (CET)]

D-alanyl-D-alanine carrier protein ligase, alanylation of teichoic acid provides some resistance against positively charged antimicrobial peptides
locus
BSU38500
pI
4.00
mw
55.00 kDa
function
biosynthesis of teichoic acid
product
D-alanyl-D-alanine carrier protein ligase
essential
no
ec
6.1.1.13
synonyms
ipa-5r, dae

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.1|Cell wall synthesis] → [category|SW 1.1.1.4|Biosynthesis of teichoic acid]
  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.1|Biosynthesis of cell wall components] → [category|SW 2.6.1.3|Biosynthesis of teichoic acid]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.2|Cell envelope stress proteins (controlled by SigM, V, W, X, Y)]
  • [SW|Categories] containing this gene/protein

  • [SW|cell wall synthesis], [SW|biosynthesis of cell wall components], [SW|cell envelope stress proteins (controlled by SigM, V, W, X, Y)]
  • This gene is a member of the following [SW|regulons]

  • [SW|SigD regulon], [SW|SigM regulon], [SW|SigX regulon], [SW|Spo0A regulon], [SW|stringent response], [SW|YvrHb regulon]
  • Gene

    Coordinates on the chromosome (coding sequence)
    3,952,275 -> 3,953,786

    Phenotypes of a mutant

  • increased sensitivity to lysozyme [Pubmed|21856855]
  • more sensitive to nisin [Pubmed|23980836]
  • The protein

    Catalyzed reaction/ biological activity

  • ATP D-alanine poly(ribitol phosphate) = AMP diphosphate O-D-alanyl-poly(ribitol phosphate) (according to Swiss-Prot)
  • Protein family

  • DltA subfamily (according to Swiss-Prot)
  • Structure

  • [PDB|3E7X]
  • [SW|Localization]

  • cytoplasm (according to Swiss-Prot)
  • Expression and Regulation

    Operon

  • ''[protein|search|dltA]-[protein|search|dltB]-[protein|search|dltC]-[protein|search|dltD]-[protein|search|dltE]'' [Pubmed|7797557]
  • [SW|Sigma factor]

  • [protein|search|SigD] [Pubmed|7797557], [protein|search|SigM] [Pubmed|18179421], [protein|search|SigX] [Pubmed|14762009]
  • Regulation

  • [protein|search|RelA] dependent downregulation (Class I) during stringent response [Pubmed|11948165]
  • repressed under conditions that trigger sporulation ([SW|Spo0A]) [Pubmed|7797557]
  • expression is reduced in a [protein|search|SigV] mutant [Pubmed|21926231]
  • Regulatory mechanism

  • activated by [SW|YvrHb] [Pubmed|16306698]
  • [SW|Spo0A]: transcription repression [Pubmed|7797557]
  • Labs working on this gene/protein

  • [SW|Mohamed Marahiel], Marburg University, Germany [http://www.uni-marburg.de/fb15/fachgebiete/bio/marahiel?language_sync=1 homepage]
  • References

    Reviews

  • 24819367
  • Original publications

  • 14762009,15955059,18784082,23980836,7797557,19324056,16306698,21856855,21926231