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rpsD [Wed Aug 31 2016 18:01:03 GMT+0200 (CEST)]
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rpsD [Wed Aug 31 2016 18:01:03 GMT+0200 (CEST)]

ribosomal protein
locus
BSU29660
pI
10.00
mw
22.00 kDa
function
translation
product
ribosomal protein S4 (BS4)
essential
yes
synonyms

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.4|Ribosomal proteins]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • [category|SW 6|Groups of genes] → [category|SW 6.5|Universally conserved proteins]
  • [SW|Categories] containing this gene/protein

  • [SW|translation], [SW|essential genes], [SW|universally conserved proteins]
  • This gene is a member of the following [SW|regulons]

  • [SW|stringent response]
  • Gene

    Coordinates on the chromosome (coding sequence)
    3,035,730 -> 3,036,332

    Phenotypes of a mutant

  • essential [Pubmed|23002217,12682299]
  • The protein

    Protein family

  • [SW|ribosomal protein] S4P family (according to Swiss-Prot)
  • Structure

  • [PDB|1C06] (Geobacillus stearothermophilus)
  • [PDB|3J9W] (the [SW|ribosome]) [Pubmed|25903689]
  • Expression and Regulation

    Operon

  • ''[protein|search|rpsD]'' [Pubmed|1699930]
  • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|1699930]
  • Regulation

  • [protein|search|RelA] dependent downregulation (Class I) during stringent response [Pubmed|11948165]
  • autorepression of ''rpsD'' expression upon binding of excess [protein|search|RpsD] to a [SW|RNA switch] in the untranslated region of the ''rpsD'' mRNA [Pubmed|23611891,1906866]
  • expression is reduced during ethanol stress due to the action of the antisense RNA [protein|search|S1136-1134] [Pubmed|26115952]
  • References

  • 1699930,2121712,6420647,1400226,1906866,19653700,11489846,23611891,23002217,25548247,25548248,26115952,25903689