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folE [Wed Feb 15 2017 18:07:28 GMT+0100 (CET)]
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folE [Wed Feb 15 2017 18:07:28 GMT+0100 (CET)]

GTP cyclohydrolase I
locus
BSU22780
pI
6.00
mw
21.00 kDa
function
biosynthesis of folate
product
GTP cyclohydrolase IA
essential
yes
ec
3.5.4.16
synonyms
mtrA

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.5|Biosynthesis of folate]
  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.8|tRNA modification and maturation]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • [SW|Categories] containing this gene/protein

  • [SW|biosynthesis of cofactors]
  • Gene

    Coordinates on the chromosome (coding sequence)
    2,384,783 -> 2,385,355

    Phenotypes of a mutant

  • essential [Pubmed|28189581]
  • The protein

    Catalyzed reaction/ biological activity

  • GTP H2O = formate 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate (according to Swiss-Prot)
  • Protein family

  • citrate synthase family (according to Swiss-Prot)
  • [SW|Cofactors]

  • zinc-dependent enzyme [Pubmed|19767425]
  • Structure

  • [PDB|3D2O] (enzyme from ''Neisseria gonorrhoeae'') [Pubmed|17032654]
  • Expression and Regulation

    Operon

  • ''[protein|search|folE]-[protein|search|mtrB]'' [Pubmed|2123343]
  • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|2123343]
  • Regulation

  • constitutive [Pubmed|19767425]
  • References

  • 1551827,2123343,17032654,19767425,28189581