SubtiBank SubtiBank
folE
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folE

GTP cyclohydrolase I, required for the initial step of queuosine synthesis ([SW|tRNA modification])
locus
BSU_22780
pI
6.34
mw
21.07 kDa
protein length
190 aa Sequence Blast
gene length
573 bp Sequence Blast
function
biosynthesis of folate and queuosine
product
GTP cyclohydrolase IA
essential
yes
ec
3.5.4.16
synonyms

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.5|Biosynthesis of folate]
  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.8|tRNA modification and maturation]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • Gene

    Coordinates
    2,384,783 2,385,355

    Phenotypes of a mutant

  • essential [Pubmed|28189581]
  • The protein

    Catalyzed reaction/ biological activity

  • GTP + H2O --> 7,8-dihydroneopterin 3'-triphosphate + formate + H+ (according to UniProt)
  • Protein family

  • GTP cyclohydrolase I family (with [protein|5F96500CC46CC4DAECEBAD34EC50B10548E6D0F9|QueF], according to UniProt)
  • [SW|Cofactors]

  • zinc-dependent enzyme [Pubmed|19767425]
  • Effectors of protein activity

  • the interaction with ZagA/ZTP facilitates the supply of zinc to FolE under conditions of zinc limitation, and thus enzymatic activity [pubmed|31132310]
  • Structure

  • [PDB|3D2O] (enzyme from ''Neisseria gonorrhoeae'') [Pubmed|17032654]
  • Expression and Regulation

    Operons

    genes
    [gene|7732A37D59E2643F232F2C0AFE51BCF7A79EDE29|folE]-[gene|E030E80134E9DED6ADBC73C7C7435024CDFD38B9|mtrB]
    description
    [Pubmed|2123343]

    sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|2123343], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]
  • regulation

  • constitutive [Pubmed|19767425]
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    References

    Reviews

  • 31220391
  • Original publications

  • 1551827,2123343,17032654,19767425,28189581,31132310