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dacB [Tue Dec 13 2016 11:16:34 GMT+0100 (CET)]
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dacB [Tue Dec 13 2016 11:16:34 GMT+0100 (CET)]

sporulation-specific penicillin-binding protein 5*, D-alanyl-D-alanine carboxypeptidase
locus
BSU23190
pI
9.00
mw
42.00 kDa
function
carboxypeptidase
product
penicillin-binding protein 5*, D-alanyl-D-alanine carboxypeptidase
essential
no
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.1|Cell wall synthesis] → [category|SW 1.1.1.7|Penicillin-binding proteins]
  • [category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.4|Sporulation proteins/ other]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

    • [SW|Categories] containing this gene/protein

  • [SW|cell wall synthesis], [SW|sporulation proteins], [SW|membrane proteins], [SW|penicillin-binding proteins]

    • This gene is a member of the following [SW|regulons]

  • [SW|SigE regulon]

    • Gene

    Coordinates on the chromosome (coding sequence)
    2,423,383 -> 2,424,531

    Phenotypes of a mutant

  • inactivation of ''[SW|dacB]'' reduces sporulation efficiency to 19.3% that of wild type cells [Pubmed|26735940]

    • The protein

    Catalyzed reaction/ biological activity

  • modifies degree of cross-linking of glycan strands in peptidoglycan

    • Protein family

  • peptidase S11 family (according to Swiss-Prot)

    • Structure

  • [PDB|3MFD] (beta-lactamase superfamily domain)

    • [SW|Localization]

  • cell membrane (according to Swiss-Prot)

    • Expression and Regulation

    Operon

  • ''[protein|search|dacB]-[protein|search|spmA]-[protein|search|spmB]'' [Pubmed|7642500]

    • [SW|Sigma factor]

  • [protein|search|SigE] [Pubmed|15699190,7528199]

    • Regulation

  • expressed early during sporulation in the mother cell ([protein|search|SigE]) [Pubmed|15699190,7528199]

    • Biological materials

    Mutant

  • 1A744 ( ''dacB''::''cat''), [Pubmed|1644769], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A744&Search=1A744 BGSC]
  • 1A745 ( ''dacB''::''cat''), [Pubmed|1644769], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A745&Search=1A745 BGSC]

    • References

    Reviews

  • 18266855

    • Original publications

  • 10498740,9864321,1548223,7642500,19542328,7528199,15699190,22123250,26735940