methylmalonate-semialdehyde dehydrogenase (acylating)
function
myo-inositol catabolism
product
methylmalonate-semialdehyde dehydrogenase (acylating)
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.16|Utilization of inositol][SW|Categories] containing this gene/protein
[SW|utilization of specific carbon sources]This gene is a member of the following [SW|regulons]
[SW|CcpA regulon], [SW|IolR regulon]Gene
Coordinates on the chromosome (coding sequence)
4,082,920 -> 4,084,383
The protein
Catalyzed reaction/ biological activity
NAD-dependent oxidation of methylmalonate semialdehyde (MMSA) to propionyl-CoA via acylation and deacylation stepsProtein family
IolA subfamily (according to Swiss-Prot)Paralogous protein(s)
[protein|search|YfmT], [protein|search|AldY], [protein|search|YcbD], [protein|search|GabD], [protein|search|GbsA], [protein|search|DhaS], [protein|search|PutC], [protein|search|RocA], [protein|search|AldX], [protein|search|YwdH][SW|Cofactors]
Coenzyme A, NAD [Pubmed|22782904]Structure
[PDB|1T90] [Pubmed|22782904]Expression and Regulation
Operon
''[protein|search|iolA]-[protein|search|iolB]-[protein|search|iolC]-[protein|search|iolD]-[protein|search|iolE]-[protein|search|iolF]-[protein|search|iolG]-[protein|search|iolH]-[protein|search|iolI]-[protein|search|iolJ]'' [Pubmed|9226270][SW|Sigma factor]
[protein|search|SigA] [Pubmed|9226270]Regulation
repressed by glucose ([protein|search|CcpA]) [Pubmed|10666464]induced by inositol ([protein|search|IolR]) [Pubmed|9887260,9226270]Regulatory mechanism
[protein|search|IolR]: transcription repression [Pubmed|9887260,9226270][protein|search|CcpA]: transcription repression [Pubmed|10666464]Labs working on this gene/protein
[SW|Yasutaro Fujita], University of Fukuyama, Japan[[Ken-ichi Yoshida]], Kobe University, JapanReferences
9226270,11566986,10666464,18310071,9887260,9887260,18310071,16332250,22900538 
