3-deoxy-D-arabino-heptulosonate 7-phosphate synthase / chorismate mutase-isozyme 3
function
biosynthesis of aromatic amino acids
product
3-deoxy-D-arabino-heptulosonate 7-phosphate synthase /
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.13|Biosynthesis/ acquisition of aromatic amino acids][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.1|Phosphorylation on an Arg residue][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.5|Phosphorylation on a Ser residue][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.6|Phosphorylation on a Thr residue][SW|Categories] containing this gene/protein
[SW|biosynthesis/ acquisition of amino acids], [SW|phosphoproteins], [SW|most abundant proteins]Gene
Coordinates on the chromosome (coding sequence)
3,045,445 -> 3,046,521
The protein
Catalyzed reaction/ biological activity
Phosphoenolpyruvate D-erythrose 4-phosphate H2O = 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate phosphate (according to Swiss-Prot) Protein family
class-I DAHP synthetase family (according to Swiss-Prot)Modification
phosphorylation on Ser-2 [Pubmed|17218307]phosphorylation on Thr-4 [Pubmed|17726680]phosphorylated on Arg-45 and Arg-301 [Pubmed|22517742]Cys126 is S-bacillithiolated by NaOCl stress in B. subtilis and other Bacillus species [Pubmed|22938038]Effectors of protein activity
subject to feedback inhibition [Pubmed|19258532]Structure
[PDB|1VR6] (from ''Thermotoga maritima'', 51% identity, 68% similarity)Expression and Regulation
Operon
''[protein|search|aroA]'' [Pubmed|9387221]Additional information
subject to feedback inhibition [http://www.ncbi.nlm.nih.gov/sites/entrez/19258532 PubMed]belongs to the 100 [[most abundant proteins]] [PubMed|15378759]References
22938038,9387221,19258532,17726680,17218307,22517742,15378759 
