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opuCA [Fri Dec 09 2016 16:21:56 GMT+0100 (CET)]
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opuCA [Fri Dec 09 2016 16:21:56 GMT+0100 (CET)]

glycine betaine/carnitine/choline ABC transporter (ATP-binding protein)
locus
BSU33830
pI
6.00
mw
43.00 kDa
function
compatible solute transport
product
glycine betaine/carnitine/choline
ABC transporter (ATP-binding protein)
essential
no
synonyms
yvbE

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.1|ABC transporters] → [category|SW 1.2.1.1|Importers] → [category|SW 1.2.1.1.4|Uptake of compatible solutes for osmoprotection]
  • [category|SW 3|Information processing] → [category|SW 3.5|Targets of second messengers] → [category|SW 3.5.1|Targets of c-di-AMP]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.6|Coping with hyper-osmotic stress]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]
  • [SW|Categories] containing this gene/protein

  • [SW|ABC transporters], [SW|coping with hyper-osmotic stress], [SW|membrane proteins]
  • This gene is a member of the following [SW|regulons]

  • [SW|OpcR regulon], [SW|RemA regulon]
  • Gene

    Coordinates on the chromosome (coding sequence)
    3,469,860 -> 3,471,002

    The protein

    Protein family

  • [SW|ABC transporter] family (according to Swiss-Prot)
  • Paralogous protein(s)

  • [SW|OpuBA]
  • [SW|Domains]

  • 2 [SW|CBS domain]s (255-314, 315-373)
  • [SW|Localization]

  • associated to the membrane (via [SW|OpuCB]-[SW|OpuCD]) [Pubmed|10092453,18763711]
  • [SW|Interactions]

  • [SW|OpuCA]-([SW|OpuCB]-[SW|OpuCD])-[SW|OpuCC] [Pubmed|10092453]
  • Expression and Regulation

    Operon

  • ''[SW|opuCA]-[SW|opuCB]-[SW|opuCC]-[SW|opuCD]'' [Pubmed|10216873]
  • Regulation

  • induced by salt stress [Pubmed|23960087,10216873]
  • repressed by choline ([protein|search|OpcR]) [Pubmed|23960087]
  • Regulatory mechanism

  • [protein|search|OpcR]: transcription repression [Pubmed|23960087]
  • [protein|search|RemA]: transcription activation [Pubmed|23646920]
  • Biological materials

    Expression vector

  • pGP2939 (N-terminal His-tag, purification from ''E. coli'', in [SW|pWH844]), available in [SW|Jörg Stülke]'s lab
  • References

  • 10092453,9925583,10216873,18763711,21296969,23960087,23646920