opuCA [2017-07-30 17:05:37]

glycine betaine/carnitine/choline ABC transporter (ATP-binding protein)

locus: BSU33830

pI: 6.55

mw: 43.09 kDa

protein length: 380 aa

gene length: 1140 bp

function: compatible solute transport

product: glycine betaine/carnitine/choline ABC transporter (ATP-binding protein)

essential: no

synonyms: yvbE

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.1|ABC transporters] → [category|SW 1.2.1.1|Importers] → [category|SW 1.2.1.1.4|Uptake of compatible solutes for osmoprotection]
• [category|SW 3|Information processing] → [category|SW 3.5|Targets of second messengers] → [category|SW 3.5.1|Targets of c-di-AMP]
• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.6|Coping with hyper-osmotic stress]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

Gene

Coordinates: 3,469,860 → 3,471,002

The protein

Protein family

• [SW|ABC transporter] family (according to Swiss-Prot)

Paralogous protein(s)

• [protein|FB2220730013A98D7C979062A4A451518B92DF09|OpuAA], [protein|3F502A4DCB1DAD7C3F968465B13C35213240515B|OpuBA]

[SW|Domains]

• 2 [SW|CBS domain]s (255-314, 315-373)

Structure

• [PDB|2IT1] (from Pyrococcus horikoshii, 35% identity)

[SW|Localization]

• associated to the membrane (via [protein|83C45215AC86FACB08CF36EB5F9E6B076D7D0F0F|OpuCB]-[protein|76C8D6BF2CA1FA5E7392C52FFD55FD01EF5AB9DC|OpuCD]) [Pubmed|10092453,18763711]

Biological materials

Expression vector

• pGP2939 (N-terminal His-tag, purification from ''E. coli'', in [SW|pWH844]), available in [SW|Jörg Stülke]'s lab

References

Reviews

• 27935846

Original publications

• 10092453,9925583,10216873,18763711,21296969,23960087,23646920