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yciC [Tue Dec 13 2016 11:16:30 GMT+0100 (CET)]
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yciC [Tue Dec 13 2016 11:16:30 GMT+0100 (CET)]

putative metallochaperone
locus
BSU03360
pI
4.00
mw
45.00 kDa
function
zinc uptake
product
putative metallochaperone
essential
no
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.2|Trace metal homeostasis (Cu, Zn, Ni, Mn, Mo)] → [category|SW 1.3.2.3|Zinc]
  • [category|SW 3|Information processing] → [category|SW 3.5|Targets of second messengers] → [category|SW 3.5.4|Targets of ZTP]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]
  • [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.1|Phosphorylation on an Arg residue]

    • [SW|Categories] containing this gene/protein

  • [SW|trace metal homeostasis (Cu, Zn, Ni, Mn, Mo)], [SW|membrane proteins], [SW|phosphoproteins]

    • This gene is a member of the following [SW|regulons]

  • [SW|Zur regulon]

    • Gene

    Coordinates on the chromosome (coding sequence)
    366,063 -> 367,256

    The protein

    Protein family

  • cobW C-terminal domain (according to Swiss-Prot)

    • Modification

  • phosphorylated on Arg-58 [Pubmed|22517742]

    • [SW|Localization]

  • membrane associated [Pubmed|18763711]

    • Expression and Regulation

    Operon

  • ''[SW|folE2]-[protein|search|yciB]-[protein|search|yczL]-[protein|search|yciC]'' [Pubmed|9811636]
  • ''[protein|search|yczL]-[protein|search|yciC]'' [Pubmed|25649915]

    • [SW|Sigma factor]

  • ''[SW|folE2]'':[protein|search|SigA] [Pubmed|12426338]
  • ''[protein|search|yczL]'':[protein|search|SigA] [Pubmed|12426338]

    • Regulation

  • ''[SW|folE2]'': induced by zinc starvation ([protein|search|Zur]) [Pubmed|12426338]
  • ''[protein|search|yczL]'': induced by zinc starvation ([protein|search|Zur]) [Pubmed|12426338]
  • part of the second wave of induction upon zinc depletion [Pubmed|27561249]

    • Regulatory mechanism

  • ''[SW|folE2]'': [protein|search|Zur]: transcription repression in the presence of zinc [Pubmed|12426338]
  • ''[protein|search|yczL]'': [protein|search|Zur]: transcription repression in the presence of zinc [Pubmed|12426338]

    • Labs working on this gene/protein

  • [SW|John Helmann], Cornell University, USA [http://www.micro.cornell.edu/research/labs/helmann-lab/index.cfm Homepage]

    • References

  • 12426338,9811636,18344368,22517742,18763711,23406412,27561249