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hlpB [Tue Dec 13 2016 11:16:31 GMT+0100 (CET)]
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hlpB [Tue Dec 13 2016 11:16:31 GMT+0100 (CET)]

HNH nuclease-like protein, rescues AddA-AddB-mediated recombination intermediates
locus
BSU10660
pI
9.00
mw
11.00 kDa
function
rescuing of AddA-AddB-mediated recombination intermediates
product
HNH nuclease-like protein
essential
yes
synonyms
yisB

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.5|DNA repair/ recombination]
  • [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.5|DNA repair/ recombination] → [category|SW 3.1.5.6|Other proteins]
  • [SW|Categories] containing this gene/protein

  • [SW|DNA repair/ recombination], [SW|essential genes]
  • This gene is a member of the following [SW|regulons]

  • [SW|ComK regulon]
  • Gene

    Coordinates on the chromosome (coding sequence)
    1,148,155 -> 1,148,457

    Phenotypes of a mutant

  • essential, the mutation can be suppressed by second-site mutations in ''[protein|search|addA]'' or ''[protein|search|addB]'' [Pubmed|22984257]
  • The protein

    [SW|Localization]

  • evenly distributed throughout the cytosol in growing cells [Pubmed|22984257]
  • forms a single focus on the nucleoid upon induction of DNA damage [Pubmed|22984257]
  • Expression and Regulation

    Operon

  • ''[protein|search|addB]-[protein|search|addA]-[protein|search|sbcD]-[protein|search|sbcC]-[protein|search|hlpB]'' [Pubmed|22383849]
  • Regulation

  • positive regulation by [protein|search|ComK] [Pubmed|11948146]
  • Biological materials

    Mutant

  • MGNA-A503 (yisB::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/503 NBRP B. subtilis, Japan]
  • References

  • 11948146,22984257,22383849