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cotA [2017-8-11 16:0:3]
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cotA [2017-8-11 16:0:3]

laccase, bilirubin oxidase, spore coat protein (outer)
locus
BSU06300
pI
5.89
mw
58.33 kDa
protein length
513 aa Sequence Blast
gene length
1539 bp Sequence Blast
function
resistance of the spore
product
laccase, bilirubin oxidase
essential
no
ec
1.3.3.5
synonyms
pig
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.1|Spore coat proteins] → [category|SW 4.2.1.1.5|Class V]
  • [category|SW 6|Groups of genes] → [category|SW 6.11|Efp-dependent proteins]

    • Gene

    Coordinates
    683,462 → 685,003

    The protein

    Structure

  • [PDB|2BHF] (reduced form)

    • [SW|Localization]

  • outer spore coat, more abundant at the mother cell-distal pole of the forespore, localization depends on [protein|825AD8D4315A85CD384F9AF6AD894E38E57C88F7|CotE] [Pubmed|22171814,19933362]

    • Expression and Regulation

    Operons

    genes
    [gene|73473E6556D374C8623A426E075038AD01AB7025|cotA]
    description
    [Pubmed|22383849]

    sigma factors

  • [protein|24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4|SigK]: sigma factor, [Pubmed|15699190,3135411], in [regulon|24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4|SigK regulon]

    • regulatory mechanism

  • [protein|19228BAD44E6DA3DE908DC390FDF628C18D94E65|GerE]: repression, [Pubmed|15383836], in [regulon|19228BAD44E6DA3DE908DC390FDF628C18D94E65|GerE regulon]

    • regulation

  • expressed late during sporulation in the mother cell ([protein|search|SigK], [protein|search|GerE]) [Pubmed|15383836]

    • additional information

  • [protein|search|translation] is likely to require [protein|search|Efp] due to the presence of several consecutive proline residues [PubMed|23239624,23239623]
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    Biological materials

    Mutant

  • 1S101 ( ''cotA''::''cat''), [Pubmed|2821284], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1S101&Search=1S101 BGSC]
  • 1S134 ( ''cotA''::''kan''), [Pubmed|11514528], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1S134&Search=1S134 BGSC]

    • References

    Reviews

  • 23202530

    • Original publications

  • 15699190,3135411,11514528,1518043,2821284,19933362,20200715,20551082,20822511,21369750,22281748,23859715,22171814,22410485,15383836,26062535,24293734,24733162,25259857,25847445,26784443,27050268,28870294