SubtiBank SubtiBank
mhqA
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mhqA

hydroquinone-specific dioxygenase, confers resistence to methyl-hydroxyquinone
locus
BSU12870
pI
5.40
mw
35.23 kDa
protein length
316 aa Sequence Blast
gene length
951 bp Sequence Blast
function
resistence to methyl-hydroxyquinone
product
hydroquinone-specific dioxygenase
essential
no
synonyms
ykcA

Genomic Context

      

categories

  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.8|Resistance against oxidative and electrophile stress]
  • Gene

    Coordinates
    1,353,080 1,354,030

    The protein

    Protein family

  • extradiol ring-cleavage dioxygenase family (according to Swiss-Prot)
  • Paralogous protein(s)

  • [protein|A1CB3DCF2EC78B9B0585CA6AC6F5BB37B8AF0208|MhqE], [protein|ACAFB2072E74CC059B492A31EF492028B96C569F|MhqO]
  • Structure

  • [PDB|3OAJ] ([protein|ACAFB2072E74CC059B492A31EF492028B96C569F|MhqO], 34% identical residues)
  • [SW|Localization]

  • cytoplasm (according to Swiss-Prot)
  • Expression and Regulation

    Operons

    genes
    [gene|7334017333600B876030056BE9247AD4E8996A1D|mhqA]
    description
    [Pubmed|17725564]

    sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|17725564], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]
  • regulatory mechanism

  • [protein|997B828A99D6D8460712C18ED0CE566B285C22DC|MhqR]: repression, [Pubmed|17725564], in [regulon|997B828A99D6D8460712C18ED0CE566B285C22DC|MhqR regulon]
  • regulation

  • induced by catechol and 2-methylhydroquinone ([protein|search|MhqR]) [Pubmed|17725564]
  • view in new tab

    Biological materials

    Mutant

  • MGNA-A737 (ykcA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/737 NBRP B. subtilis, Japan]
  • BKE12870 ([gene|7334017333600B876030056BE9247AD4E8996A1D|mhqA]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE12870 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATGCTGTCCCTCCAGGT, downstream forward: _UP4_TAAATTGTGATTCTTTTGCC
  • BKK12870 ([gene|7334017333600B876030056BE9247AD4E8996A1D|mhqA]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK12870 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATGCTGTCCCTCCAGGT, downstream forward: _UP4_TAAATTGTGATTCTTTTGCC
  • References

  • 17407181,17725564,27965289