SubtiBank SubtiBank
ctaC
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ctaC

cytochrome-c oxidase (subunit II)
locus
BSU_14890
pI
8.64
mw
39.94 kDa
protein length
356 aa Sequence Blast
gene length
1071 bp Sequence Blast
function
respiration
product
cytochrome-c oxidase (subunit II)
essential
no
ec
1.9.3.1
synonyms

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.1|Electron transport and ATP synthesis] → [category|SW 2.1.2|Respiration] → [category|SW 2.1.2.1|Terminal oxidases]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]
  • Gene

    Coordinates
    1,560,466 1,561,536

    The protein

    Catalyzed reaction/ biological activity

  • 4 [Fe(II)cytochrome c] + 4 H+ + O2 --> 4 [Fe(III)cytochrome c] + 2 H2O (according to UniProt)
  • Protein family

  • cytochrome c oxidase subunit 2 family (with [protein|48A9E1E39838BFFCF12CADF0A8D8E6FFDCA6F175|QoxA], according to UniProt)
  • [SW|Domains]

  • Cytochrome c domain (aa 258-356) (according to UniProt)
  • [SW|Cofactors]

  • Cu(A) [Pubmed|10837475]
  • Structure

  • [PDB|2YEV] (from Thermus thermophilus, 35% identity) [pubmed|22763450]
  • [SW|Localization]

  • cell membrane [Pubmed|23880299]
  • Expression and Regulation

    Operons

    genes
    [gene|83F5D5FCCAFADB7231ACD9BE7941820240954C70|ctaB]-[gene|72D5442C0EF3B404F7B615366E357B68C863CEB6|ctaC]-[gene|20D1174554A03EECE233A1A045F6DF83AF799959|ctaD]-[gene|9DF8423F1D63ED3928B2818F58BC3DECCDBB1DDB|ctaE]-[gene|28E5AF86CE49D7B0ECBFAF9ED5C1FC65D9F810EA|ctaF]-[gene|8C16E115CB59A74C24954BFCDE112720BA09D5EA|ctaG]
    description
    [Pubmed|9829923]

    regulatory mechanism

  • [protein|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|ResD]: activation, [Pubmed|9829923], in [regulon|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|ResD regulon]
  • [protein|5872812AB61E92E2944E926915EB7FEE71BFA6D5|Abh]: repression, synergistic repression with [protein|E5110D9C36E8C55AFD1419987B14A53232165F20|AbrB], in [regulon|5872812AB61E92E2944E926915EB7FEE71BFA6D5|Abh regulon]
  • [protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|CcpA]: repression, in [regulon|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|CcpA regulon]
  • [protein|E5110D9C36E8C55AFD1419987B14A53232165F20|AbrB]: repression, synergistic repression with [protein|5872812AB61E92E2944E926915EB7FEE71BFA6D5|Abh], in [regulon|E5110D9C36E8C55AFD1419987B14A53232165F20|AbrB regulon]
  • regulation

  • expressed under anaerobic conditions ([protein|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|ResD]) [Pubmed|9829923]
  • view in new tab

    Biological materials

    Mutant

  • BKE14890 ([gene|72D5442C0EF3B404F7B615366E357B68C863CEB6|ctaC]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE14890 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTTCACCCAACCCCTTTT, downstream forward: _UP4_TAGGGAAGAAAGGGAGATAT
  • BKK14890 ([gene|72D5442C0EF3B404F7B615366E357B68C863CEB6|ctaC]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK14890 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTTCACCCAACCCCTTTT, downstream forward: _UP4_TAGGGAAGAAAGGGAGATAT
  • References

  • 9882689,1685007,10551842,9829923,12850135,23599347,20817675,23880299,10837475,27503613,22763450