yeaB [2017-8-11 16:0:3]

secondary manganese (II) efflux pump

locus: BSU06320

pI: 5.63

mw: 31.63 kDa

protein length: 290 aa

gene length: 870 bp

function: Mn(II) export

product: manganese (II) efflux pump

essential: no

synonyms: ydxT,yeaB

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.4|Transporters/ other] → [category|SW 1.2.4.11|Other exporters]
• [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.4|Transporters/ other] → [category|SW 1.2.4.13|Metal ion exporters]
• [category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.2|Trace metal homeostasis (Cu, Zn, Ni, Mn, Mo)] → [category|SW 1.3.2.2|Manganese]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

Gene

Coordinates: 686,962 → 687,834

The protein

Catalyzed reaction/ biological activity

• efflux of Mn(II) [Pubmed|27748968]

Protein family

• cation diffusion facilitator (CDF) family [Pubmed|27748968]

[SW|Localization]

• cell membrane (according to Swiss-Prot)

Expression and Regulation

Operons

• genes: [gene|72BF9B934CB5800E156263FF377DED0AD2E920A9|mneS]
  description: [pubmed|22383849]

  sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|27748968], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]

  regulatory mechanism

  • [protein|FF34DC303E8A7C9FAA205A6C2924961963B14EB1|MntR]: transcription activation, [Pubmed|27748968], in [regulon|FF34DC303E8A7C9FAA205A6C2924961963B14EB1|MntR regulon]

Biological materials

Mutant

• MGNA-A914 (yeaB::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/914 NBRP B. subtilis, Japan]

References

• 27748968