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tagA
UDP-N-acetyl-D-mannosamine transferase
function
biosynthesis of teichoic acid
product
UDP-N-acetyl-D-mannosamine transferase
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.1|Cell wall synthesis] → [category|SW 1.1.1.4|Biosynthesis of teichoic acid][category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.1|Biosynthesis of cell wall components] → [category|SW 2.6.1.3|Biosynthesis of teichoic acid][category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]Gene
Coordinates
3,681,370 3,682,140
Phenotypes of a mutant
essential [Pubmed|12682299], reduced growth rate, loss of rod-like morphology [Pubmed|19376878]inactivation of ''[gene|72A89412C53703F96F835D26307263F5D1A4AB4E|tagA]'' strongly restores beta-lactam resistance in a ''[gene|081DF3EE9FA56209D648C7677188C61CE3AA8E41|sigM]'' mutant [Pubmed|22211522]The protein
Catalyzed reaction/ biological activity
N-acetyl-α-D-glucosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + UDP-N-acetyl-α-D-mannosamine --> H+ + N-acetyl-β-D-mannosaminyl-(1→4)-N-acetyl-α-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + UDP (according to UniProt)Protein family
glycosyltransferase 26 family (single member, according to UniProt)Structure
[PDB|5WB4] (from Thermoanaerobacter italicus, corresponds to aa 35 ... 194, 33% identity)[SW|Localization]
secreted (according to Swiss-Prot)References
Reviews
Original publications
18156271,9457886,9683503,7952180,7581998,19376878,12950927,22211522,25666134,29794222