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nupO [Tue Dec 13 2016 11:16:36 GMT+0100 (CET)]
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nupO [Tue Dec 13 2016 11:16:36 GMT+0100 (CET)]

ABC transporter for guanosine (ATP-binding protein)
locus
BSU31550
pI
7.50
mw
56.00 kDa
function
uptake of guanosine
product
ABC transporter for guanosine
essential
no
synonyms
yufO

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.1|ABC transporters] → [category|SW 1.2.1.1|Importers] → [category|SW 1.2.1.1.1|Uptake of carbon sources]
  • [category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.2|Biosynthesis/ acquisition of nucleotides] → [category|SW 2.5.2.1|Biosynthesis/ acquisition of purine nucleotides]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]
  • [SW|Categories] containing this gene/protein

  • [SW|ABC transporters], [SW|biosynthesis/ acquisition of nucleotides], [SW|membrane proteins]
  • This gene is a member of the following [SW|regulons]

  • [SW|CodY regulon]
  • Gene

    Coordinates on the chromosome (coding sequence)
    3,241,085 -> 3,242,617

    Phenotypes of a mutant

  • a ''[protein|search|nupO] [protein|search|nupG]'' double mutant is unable to utilize externally provided guanosine [Pubmed|21926227]
  • defective in the the ability to support the growth of ''Synechococcus leopoliensis'' CCAP1405/1 on agar media [Pubmed|25875741]
  • The protein

    Protein family

  • [SW|ABC transporter] family (according to Swiss-Prot)
  • [SW|Localization]

  • associated to the membrane (via [protein|search|NupP]-[protein|search|NupQ]) [Pubmed|10092453]
  • [SW|Interactions]

  • [protein|search|NupO]-([protein|search|NupP]-[protein|search|NupQ]) [Pubmed|10092453]
  • Expression and Regulation

    Operon

  • ''[protein|search|nupN]-[protein|search|nupO]-[protein|search|nupP]-[protein|search|nupQ]'' [Pubmed|21926227]
  • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|21926227]
  • Regulation

  • repressed during growth in the presence of branched chain amino acids ([protein|search|CodY]) [Pubmed|12618455,21699902,21926227]
  • Regulatory mechanism

  • [protein|search|CodY]: transcription repression [Pubmed|12618455,21699902,21926227]
  • References

  • 10092453,21926227,12618455,25875741