alpha-phosphoglucomutase, required for UDP-glucose synthesis, inhibits FtsZ ring assembly (indirect effect due to a defect in UDP-glucose synthesis)
function
interconversion of glucose 6-phosphate and alpha-glucose 1-phosphate
product
alpha-phosphoglucomutase
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.1|Cell wall synthesis] → [category|SW 1.1.1.1|Biosynthesis of peptidoglycan][category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.1|Cell wall synthesis] → [category|SW 1.1.1.4|Biosynthesis of teichoic acid][category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.3|Lipid metabolism/ other][category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.1|Biosynthesis of cell wall components] → [category|SW 2.6.1.1|Biosynthesis of peptidoglycan][category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.1|Biosynthesis of cell wall components] → [category|SW 2.6.1.3|Biosynthesis of teichoic acid][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.8|Phosphorylation on either a Ser, Thr or Tyr residue][SW|Categories] containing this gene/protein
[SW|cell wall synthesis], [SW|lipid metabolism/ other], [SW|phosphoproteins], [SW|sporulation/ other]Gene
Coordinates on the chromosome (coding sequence)
1,006,774 -> 1,008,519
Phenotypes of a mutant
cells are bent and distended due to the lack of glucolipids [Pubmed|27684739]the inactivation of ''[protein|search|pgcA]'' suppresses the poor and filamentous growth of the ''[protein|search|yvcL] [protein|search|zapA]'' double mutant [Pubmed|24097947]inactivation of ''[SW|pgcA]'' reduces sporulation efficiency to 0.1% that of wild type cells; smaller and wider mother cells with small forespores [Pubmed|26735940]The protein
Catalyzed reaction/ biological activity
Alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate (according to Swiss-Prot)Protein family
phosphohexose mutase family (according to Swiss-Prot)Modification
phosphorylated on ser/ thr/ tyr [Pubmed|16493705], [Pubmed|17726680]Additional information
PgcA inhibits [protein|search|FtsZ] ring assembly (indirect effect due to a defect in UDP-glucose synthesis)[Pubmed|17662947]Biological materials
Mutant
MGNA-B476 (yhxB::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1475 NBRP B. subtilis, Japan]GP1743: ''pgcA::aphA3'', available in [SW|Jörg Stülke]' labReferences
Reviews
Original publications
15175311,17726680,16493705,15640167,17662947,22396664,24097947,26735940,27684739 
