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transcriptional antiterminator of the pyr operon
function
regulation of pyrimidine biosynthesis
product
transcriptional antiterminator with minor uracil
phosphoribosyltransferase activity
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.2|Biosynthesis/ acquisition of nucleotides] → [category|SW 2.5.2.4|Biosynthesis/ acquisition of pyrimidine nucleotides][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.4|RNA binding regulators][SW|Categories] containing this gene/protein
[SW|biosynthesis/ acquisition of nucleotides], [SW|transcription factors and their control], [SW|RNA binding regulators]This gene is a member of the following [SW|regulons]
[SW|PyrR regulon]Gene
Coordinates on the chromosome (coding sequence)
1,618,304 -> 1,618,849
The protein
Catalyzed reaction/ biological activity
UMP diphosphate = uracil 5-phospho-alpha-D-ribose 1-diphosphate (according to Swiss-Prot) Protein family
PyrR subfamily (according to Swiss-Prot)Structure
[PDB|1A3C] (dimeric form)[SW|Interactions]
[protein|search|PyrR]-[protein|search|PyrR] [Pubmed|9551555]Expression and Regulation
Operon
''[protein|search|pyrR]-[protein|search|pyrP]-[protein|search|pyrB]-[protein|search|pyrC]-[SW|pyrAA]-[SW|pyrAB]-[protein|search|pyrK]-[protein|search|pyrD]-[protein|search|pyrF]-[protein|search|pyrE]'' [Pubmed|8206849][SW|Sigma factor]
[protein|search|SigA] [Pubmed|1709162]Regulation
induced in the absence of uridine nucleotides ([protein|search|PyrR]) [Pubmed|8206849]Regulatory mechanism
[protein|search|PyrR]: [SW|RNA switch], transcription termination/ antitermination (in the presence of uridine nucleotides: termination, in their absence: antitermination) [Pubmed|8955403]References
8935652,8206849,15716449,11726695,9488732,9551555,12896995,9932459,8955403,8824632,12482852,1709162,7798145,11948166,8759868,7868607,9488732,17322189 
