SubtiBank SubtiBank
pyrR [Mon Aug 31 2015 13:54:13 GMT+0200 (CEST)]
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pyrR [Mon Aug 31 2015 13:54:13 GMT+0200 (CEST)]

transcriptional antiterminator of the pyr operon
locus
BSU15470
pI
4.00
mw
20.00 kDa
function
regulation of pyrimidine biosynthesis
product
transcriptional antiterminator with minor uracil
phosphoribosyltransferase activity
essential
no
ec
2.4.2.9
synonyms

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.2|Biosynthesis/ acquisition of nucleotides] → [category|SW 2.5.2.4|Biosynthesis/ acquisition of pyrimidine nucleotides]
  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other]
  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.4|RNA binding regulators]
  • [SW|Categories] containing this gene/protein

  • [SW|biosynthesis/ acquisition of nucleotides], [SW|transcription factors and their control], [SW|RNA binding regulators]
  • This gene is a member of the following [SW|regulons]

  • [SW|PyrR regulon]
  • Gene

    Coordinates on the chromosome (coding sequence)
    1,618,304 -> 1,618,849

    The protein

    Catalyzed reaction/ biological activity

  • UMP diphosphate = uracil 5-phospho-alpha-D-ribose 1-diphosphate (according to Swiss-Prot)
  • Protein family

  • PyrR subfamily (according to Swiss-Prot)
  • Structure

  • [PDB|1A3C] (dimeric form)
  • [SW|Interactions]

  • [protein|search|PyrR]-[protein|search|PyrR] [Pubmed|9551555]
  • Expression and Regulation

    Operon

  • ''[protein|search|pyrR]-[protein|search|pyrP]-[protein|search|pyrB]-[protein|search|pyrC]-[SW|pyrAA]-[SW|pyrAB]-[protein|search|pyrK]-[protein|search|pyrD]-[protein|search|pyrF]-[protein|search|pyrE]'' [Pubmed|8206849]
  • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|1709162]
  • Regulation

  • induced in the absence of uridine nucleotides ([protein|search|PyrR]) [Pubmed|8206849]
  • Regulatory mechanism

  • [protein|search|PyrR]: [SW|RNA switch], transcription termination/ antitermination (in the presence of uridine nucleotides: termination, in their absence: antitermination) [Pubmed|8955403]
  • References

  • 8935652,8206849,15716449,11726695,9488732,9551555,12896995,9932459,8955403,8824632,12482852,1709162,7798145,11948166,8759868,7868607,9488732,17322189