SubtiBank SubtiBank
dapG [Fri Mar 04 2016 19:15:32 GMT+0100 (CET)]
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dapG [Fri Mar 04 2016 19:15:32 GMT+0100 (CET)]

aspartokinase I (alpha and beta subunits)
locus
BSU16760
pI
5.00
mw
42.00 kDa
function
biosynthesis of lysine and peptidoglycan
product
aspartokinase I (alpha and beta subunits)
essential
no
ec
2.7.2.4
synonyms
lssD

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.1|Cell wall synthesis] → [category|SW 1.1.1.1|Biosynthesis of peptidoglycan]
  • [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.6|Biosynthesis/ acquisition of lysine/ threonine]
  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.1|Biosynthesis of cell wall components] → [category|SW 2.6.1.1|Biosynthesis of peptidoglycan]
  • [category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.4|Sporulation proteins/ other]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • [SW|Categories] containing this gene/protein

  • [SW|cell wall synthesis], [SW|biosynthesis/ acquisition of amino acids], [SW|Biosynthesis of cell wall components], [SW|sporulation proteins]
  • This gene is a member of the following [SW|regulons]

  • [SW|SigK regulon]
  • Gene

    Coordinates on the chromosome (coding sequence)
    1,747,123 -> 1,748,337

    The protein

    Catalyzed reaction/ biological activity

  • ATP L-aspartate = ADP 4-phospho-L-aspartate (according to Swiss-Prot)
  • Protein family

  • aspartokinase family (according to Swiss-Prot)
  • Paralogous protein(s)

  • [protein|search|LysC]
  • Effectors of protein activity

  • inhibited by diaminopimelic acid [Pubmed|2152900]
  • Structure

  • [PDB|1SFT] (from ''Geobacillus stearothermophilus'', 57% identity) [Pubmed|9063881]
  • Expression and Regulation

    Operon

  • ''[SW|spoVFA]-[SW|spoVFB]-[protein|search|asd]-[protein|search|dapG]-[protein|search|dapA]'' [Pubmed|8098035]
  • ''[protein|search|asd]-[protein|search|dapG]-[protein|search|dapA]'' [Pubmed|8098035]
  • [SW|Sigma factor]

  • ''[SW|spoVFA]'': [protein|search|SigK] [Pubmed|15699190,8098035]
  • ''[protein|search|asd]'': [protein|search|SigA] [Pubmed|8098035]
  • References

    Reviews

  • 19946135,22079167
  • Original publications

  • 8345520,2153658,15699190,8098035,2152900,9063881