bpsB

methyltransferase, involved in polyketide synthesis

locus: BSU_22040

pI: 9.55

mw: 19.17 kDa

protein length: 168 aa

gene length: 507 bp

function: polyketide synthesis

product: methyltransferase

essential: no

synonyms: ypbQ

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.6|Miscellaneous metabolic pathways] → [category|SW 2.6.6.1|Biosynthesis of antibacterial compounds]
• [category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.5|Newly identified sporulation proteins (based on transcription profiling)]
• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.15|Biosynthesis of antibacterial compounds]

Gene

Coordinates: 2,316,446 2,316,952

The protein

Catalyzed reaction/ biological activity

• conversion of triketide pyrones to alkylpyrone methyl ethers [Pubmed|19465653]

Expression and Regulation

Operons

• genes: [gene|7D90F7AF49BAD6A95731BF805991DEBBBCAFA46C|bpsA]-[gene|6BAF5763249305F27326F941A34956396B3F8C99|bpsB]
  description: [Pubmed|19465653]

Biological materials

Mutant

• MGNA-A876 (ypbQ::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/876 NBRP B. subtilis, Japan]
• BKE22040 ([gene|6BAF5763249305F27326F941A34956396B3F8C99|bpsB]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE22040 BGSC], [Pubmed|28189581], upstream reverse: _UP1_GGCGATCAACAACCAAAACA, downstream forward: _UP4_TAGCGATTGAAAATCATTCT
• BKK22040 ([gene|6BAF5763249305F27326F941A34956396B3F8C99|bpsB]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK22040 BGSC], [Pubmed|28189581], upstream reverse: _UP1_GGCGATCAACAACCAAAACA, downstream forward: _UP4_TAGCGATTGAAAATCATTCT

References

• 19465653,20525796