tRNA methylthiotransferase
product
tRNA methylthiotransferase
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.8|tRNA modification and maturation][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.4|Heat shock proteins][SW|Categories] containing this gene/protein
[SW|translation], [SW|heat shock proteins], [SW|membrane proteins]This gene is a member of the following [SW|regulons]
[SW|HrcA regulon]Gene
Coordinates on the chromosome (coding sequence)
2,621,677 -> 2,623,032
The protein
Catalyzed reaction/ biological activity
modification of N(6)-threonylcarbamoyladenosine (t(6)A) to 2-methylthio-N(6)-threonylcarbamoyladenosine (ms(2)t(6)A) in tRNA [Pubmed|27913733,20472640]Protein family
YqeV subfamily (according to Swiss-Prot)Paralogous protein(s)
[protein|search|YmcB][SW|Cofactors]
2 (4Fe-4S) clusters [Pubmed|20584901]Structure
[PDB|4JC0] (from ''Thermotoga maritima'', 29% identity) [Pubmed|23542644][SW|Localization]
cell membrane (according to Swiss-Prot)Expression and Regulation
Operon
''[protein|search|hrcA]-[protein|search|grpE]-[protein|search|dnaK]-[protein|search|dnaJ]-[protein|search|yqeT]-[protein|search|yqeU]-[protein|search|mtaB]'' [Pubmed|9023197][SW|Sigma factor]
[protein|search|SigA] [Pubmed|1339421]Regulation
induced by heat shock ([protein|search|HrcA]) [Pubmed|1339421]Regulatory mechanism
[protein|search|HrcA]: transcription repression [Pubmed|1339421]References
10383760,9023197,7592421,20472640,20584901,27913733,23542644 
