qdoI [Tue Dec 13 2016 11:16:37 GMT+0100 (CET)]

Fe-containing quercetin 2,3-dioxygenase

locus: BSU39980

pI: 5.00

mw: 37.00 kDa

function: resistance to plant product quercetin

product: Fe-containing quercetin 2,3-dioxygenase

essential: no

synonyms: yxaG

Genomic Context

categories

• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.10|Resistance against other toxic compounds (nitric oxide, phenolic acids, flavonoids, oxalate)]

[SW|Categories] containing this gene/protein

• [SW|resistance against other toxic compounds (nitric oxide, phenolic acids, flavonoids, oxalate)]

This gene is a member of the following [SW|regulons]

• [SW|LmrA regulon], [SW|QdoR regulon]

Gene

Coordinates on the chromosome (coding sequence): 4,106,245 -> 4,107,258

The protein

Catalyzed reaction/ biological activity

• oxidation of the flavonol quercetin with dioxygen, cleaving the central heterocyclic ring and releasing CO

Protein family

• bicupin family

[SW|Cofactors]

• Mn(II) (preferred), but also active with Fe(II) snd Co(II) [Pubmed|22084064]

Structure

• [PDB|1Y3T] [Pubmed|15628860]
• [PDB|2H0V]

Expression and Regulation

Operon

• ''[protein|search|qdoI]-[protein|search|yxaH]'' [Pubmed|10746760]

Regulation

• induced by flavonoids such as quercetin ([protein|search|QdoR], [protein|search|LmrA]) [Pubmed|17483215]

Regulatory mechanism

• [protein|search|LmrA]: transcription repression [Pubmed|15317768]
• [protein|search|QdoR]: transcription repression [Pubmed|17483215]

Additional information

• major regulator: [protein|search|QdoR] [PubMed|17483215]

References

Reviews

• 9056848,10730195

Original publications

• 17483215,14741339,15039076,15317768,10746760,20460727,14697267,22084064,16411777,27170159,15628860