SubtiBank SubtiBank
mgsR [Tue Dec 13 2016 11:16:34 GMT+0100 (CET)]
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mgsR [Tue Dec 13 2016 11:16:34 GMT+0100 (CET)]

transcriptional regulator of a subset of the SigB general stress regulon, required for protection against oxidative stress
locus
BSU24770
pI
9.28
mw
14.00 kDa
function
controls a subset of general stress genes
product
transcriptional regulator
essential
no
synonyms
yqgZ

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.1|General stress proteins (controlled by SigB)]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.8|Resistance against oxidative and electrophile stress]
  • [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.1|Phosphorylation on an Arg residue]
  • [SW|Categories] containing this gene/protein

  • [SW|transcription factors and their control], [SW|general stress proteins (controlled by SigB)], [SW|resistance against oxidative and electrophile stress]
  • This gene is a member of the following [SW|regulons]

  • [SW|SigB regulon], [SW|MgsR regulon]
  • Gene

    Coordinates on the chromosome (coding sequence)
    2,564,026 -> 2,564,406

    The protein

    Catalyzed reaction/ biological activity

  • exerts a positive or negative effect on the expression of 53 or 18 stress genes, respectively [Pubmed|18643936]
  • Protein family

  • arsC family (according to Swiss-Prot) Arsenate Reductase (ArsC) family, Spx subfamily
  • Paralogous protein(s)

  • [protein|search|Spx]
  • Modification

  • [protein|search|MgsR] is subject to post-translational redox-sensitive activation by intramolecular disulfide bond formation in response to ethanol stress [Pubmed|22812682]
  • [SW|Interactions]

  • [protein|search|MgsR]-[protein|search|RpoA] [Pubmed|18643936]
  • Expression and Regulation

    Operon

  • ''mgsR'' [Pubmed|18643936]
  • [SW|Sigma factor]

  • [protein|search|SigB] [Pubmed|18643936]
  • Regulation

  • repressed by casamino acids [Pubmed|12107147]
  • induced by stress ([protein|search|SigB]) [Pubmed|15805528,18643936]
  • Regulatory mechanism

  • MgsR: transcription activation [Pubmed|22812682]
  • Additional information

  • [protein|search|MgsR] is subject to post-translational redox-sensitive activation by intramolecular disulfide bond formation in response to ethanol stress [PubMed|22812682]
  • [protein|search|MgsR] is subject to rapid proteolytic degradation by [protein|search|ClpX]-[protein|search|ClpP] and [protein|search|ClpC]-[protein|search|ClpP] [PubMed|22812682]
  • References

  • 18643936,12107147,15805528,18643936,22812682,22582280