transcriptional regulator of a subset of the SigB general stress regulon, required for protection against oxidative stress
function
controls a subset of general stress genes
product
transcriptional regulator
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.1|General stress proteins (controlled by SigB)][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.8|Resistance against oxidative and electrophile stress][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.1|Phosphorylation on an Arg residue][SW|Categories] containing this gene/protein
[SW|transcription factors and their control], [SW|general stress proteins (controlled by SigB)], [SW|resistance against oxidative and electrophile stress]This gene is a member of the following [SW|regulons]
[SW|SigB regulon], [SW|MgsR regulon]Gene
Coordinates on the chromosome (coding sequence)
2,564,026 -> 2,564,406
The protein
Catalyzed reaction/ biological activity
exerts a positive or negative effect on the expression of 53 or 18 stress genes, respectively [Pubmed|18643936]Protein family
arsC family (according to Swiss-Prot) Arsenate Reductase (ArsC) family, Spx subfamilyParalogous protein(s)
[protein|search|Spx]Modification
[protein|search|MgsR] is subject to post-translational redox-sensitive activation by intramolecular disulfide bond formation in response to ethanol stress [Pubmed|22812682][SW|Interactions]
[protein|search|MgsR]-[protein|search|RpoA] [Pubmed|18643936]Expression and Regulation
Operon
''mgsR'' [Pubmed|18643936][SW|Sigma factor]
[protein|search|SigB] [Pubmed|18643936]Regulation
repressed by casamino acids [Pubmed|12107147]induced by stress ([protein|search|SigB]) [Pubmed|15805528,18643936]Regulatory mechanism
MgsR: transcription activation [Pubmed|22812682]Additional information
[protein|search|MgsR] is subject to post-translational redox-sensitive activation by intramolecular disulfide bond formation in response to ethanol stress [PubMed|22812682][protein|search|MgsR] is subject to rapid proteolytic degradation by [protein|search|ClpX]-[protein|search|ClpP] and [protein|search|ClpC]-[protein|search|ClpP] [PubMed|22812682]References
18643936,12107147,15805528,18643936,22812682,22582280 
