SubtiBank SubtiBank
mgsR [2017-07-18 15:09:10]
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mgsR [2017-07-18 15:09:10]

transcriptional regulator of a subset of the SigB general stress regulon, required for protection against oxidative stress
locus
BSU24770
pI
9.28
mw
14.68 kDa
protein length
126 aa Sequence Blast
gene length
378 bp Sequence Blast
function
controls a subset of general stress genes
product
transcriptional regulator
essential
no
synonyms
yqgZ

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.1|General stress proteins (controlled by SigB)]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.8|Resistance against oxidative and electrophile stress]
  • [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.1|Phosphorylation on an Arg residue]
  • Gene

    Coordinates
    2,564,026 → 2,564,406

    The protein

    Catalyzed reaction/ biological activity

  • exerts a positive or negative effect on the expression of 53 or 18 stress genes, respectively [Pubmed|18643936]
  • Protein family

  • arsC family (according to Swiss-Prot) Arsenate Reductase (ArsC) family, Spx subfamily
  • Paralogous protein(s)

  • [protein|2C6386E9A63F410558D168798D077DF91590F454|Spx]
  • Modification

  • [protein|6A38DAA96F7BBF31FD8A4018A8CA7A72F3C28F79|MgsR] is subject to post-translational redox-sensitive activation by intramolecular disulfide bond formation in response to ethanol stress [Pubmed|22812682]
  • Expression and Regulation

    Operons

    genes
    [gene|6A38DAA96F7BBF31FD8A4018A8CA7A72F3C28F79|mgsR]
    description
    [Pubmed|18643936]

    sigma factors

  • [protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|SigB]: sigma factor, [Pubmed|18643936], in [regulon|580011DE5DC40EC9E7E0512791D328FAA010DCB8|SigB regulon]
  • regulatory mechanism

  • [protein|6A38DAA96F7BBF31FD8A4018A8CA7A72F3C28F79|MgsR]: activation, in [regulon|6A38DAA96F7BBF31FD8A4018A8CA7A72F3C28F79|MgsR regulon]
  • regulation

  • induced by stress ([protein|search|SigB]) [Pubmed|15805528,18643936]
  • additional information

  • [protein|search|MgsR] is subject to post-translational redox-sensitive activation by intramolecular disulfide bond formation in response to ethanol stress [PubMed|22812682]
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    Biological materials

    Mutant

  • MGNA-C476 (yqgZ::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2474 NBRP B. subtilis, Japan]
  • References

  • 18643936,12107147,15805528,18643936,22812682,22582280