mrgA [Mon Aug 31 2015 13:56:44 GMT+0200 (CEST)]

iron storage protein, DNA-binding stress protein, forms highly stable, multimeric protein-DNA complexes which protect against oxidative killing

locus: BSU32990

pI: 4.60

mw: 17.00 kDa

function: iron storage,

product: mini-ferritin, DNA-binding stress protein

essential: no

synonyms

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.3|Acquisition of iron] → [category|SW 1.3.3.3|Acquisition of iron / Other]
• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.5|Iron metabolism] → [category|SW 2.6.5.1|Acquisition of iron / Other]
• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.8|Resistance against oxidative and electrophile stress]

[SW|Categories] containing this gene/protein

• [SW|acquisition of iron], [SW|iron metabolism], [SW|resistance against oxidative and electrophile stress]

This gene is a member of the following [SW|regulons]

• [SW|PerR regulon]

The protein

Catalyzed reaction/ biological activity

• forms highly stable, multimeric protein-DNA complexes which protect against oxidative killing

Protein family

• dps family (according to Swiss-Prot)

Paralogous protein(s)

• [protein|search|Dps]

[SW|Cofactors]

• contains an iron-sulfur cluster

Structure

• [PDB|2CHP]

Expression and Regulation

Operon

• ''mrgA'' [Pubmed|8396117]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|14563870]

Regulation

• induced by hydrogen peroxide ([protein|search|PerR]) [Pubmed|11532148]

Regulatory mechanism

• [protein|search|PerR]: transcription repression [Pubmed|11532148]

References

Reviews

• 15222465

Original publications

• 9393687,14563870,7667267,12486061,8396117,9393707,8709848,8932315,11532148