SubtiBank SubtiBank
ftsA
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ftsA

cell division protein, membrane anchor for [protein|41872E2EF00C79918DD077F2EF78F37E24FEB110|FtsZ]
locus
BSU15280
pI
5.09
mw
47.94 kDa
protein length
440 aa Sequence Blast
gene length
1320 bp Sequence Blast
function
formation of Z-ring
product
[SW|cell division] protein
essential
yes
synonyms
spoIIN

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.8|Cell division] → [category|SW 1.1.8.2|Other genes]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]
  • Gene

    Coordinates
    1,596,474 → 1,597,796

    Phenotypes of a mutant

  • essential [Pubmed|28189581]
  • cells become elongated [Pubmed|24218584]
  • the ''[gene|672EA84D7725BE21F649DF30A11EB4E0EDFC3925|ftsA]'' mutation is synthetically lethal with a ''[gene|DB09F1C36257F511A84A083967A25A9D46744D14|sepF]'' mutation [Pubmed|24218584]
  • The protein

    Catalyzed reaction/ biological activity

  • required for septum recruitment of [protein|DF77B46666595E86081C5345C91E08F86DF9FAEE|SftA] [pubmed|29439991]
  • Protein family

  • ftsA/mreB family (according to Swiss-Prot)
  • [SW|Localization]

  • septal at the cell membrane (35% of the molecules) [Pubmed|29439991,20566861]
  • cytoplasma (65% of the molecules) [pubmed|29439991]
  • septal localization depends on the proton motive force [Pubmed|20566861]
  • Expression and Regulation

    Operons

    genes
    [gene|672EA84D7725BE21F649DF30A11EB4E0EDFC3925|ftsA]-[gene|41872E2EF00C79918DD077F2EF78F37E24FEB110|ftsZ]
    description
    [Pubmed|1569582]

    sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|1569582], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]
  • [protein|DC3449D5F195E5C2E9E14FEC95396C8F1FDF73B4|SigH]: sigma factor, [Pubmed|1569582], in [regulon|DC3449D5F195E5C2E9E14FEC95396C8F1FDF73B4|SigH regulon]
  • regulatory mechanism

  • [protein|7F340423A34CE40D1F1AA8D373F7C4B859A6496D|WalR]: activation, in [regulon|7F340423A34CE40D1F1AA8D373F7C4B859A6496D|WalR regulon]
  • regulation

  • activated by [protein|search|WalR] [Pubmed|10878122]
  • additional information

  • half-life of the ''[SW|ftsZ]'' mRNA: 2.2 min [Pubmed|26110430]
  • view in new tab

    Biological materials

    Mutant

  • 1A787 ( ''ftsA''::''cat''), [Pubmed|8071208], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A787&Search=1A787 BGSC]
  • References

    Reviews

  • 19680248,28254403
  • Original Publications

  • 29439991,16796675,12081956,16159787,11298280,18776011,9287012,1569582,10878122,7592498,20566861,23036588,23701187,24218584,24224907,24316672,28189581