function
control of SigB activity
product
activator of RsbT kinase activity, stressosome sensor protein
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.1|Sigma factors and their control] → [category|SW 3.4.1.2|Control of sigma factors][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.6|Phosphorylation on a Thr residue][SW|Categories] containing this gene/protein
[SW|sigma factors and their control], [SW|phosphoproteins], [SW|most abundant proteins]Gene
Coordinates on the chromosome (coding sequence)
519,408 -> 520,232
The protein
Catalyzed reaction/ biological activity
positive regulator of [protein|search|YtvA]-dependent light activation of the [protein|search|SigB] stress response [Pubmed|22287516]phosphorylated [protein|search|RsbR] activates the kinase activity of [protein|search|RsbT] [Pubmed|23320651]Paralogous protein(s)
[SW|RsbRB], [SW|RsbRC], [SW|RsbRD], [protein|search|YtvA][SW|Domains]
RsbRA is composed of an N-terminal nonheme globin domain and a highly conserved C-terminal STAS (Sulphate Transporter and AntiSigma factor antagonist) domain. The C-terminal STAS domain is the target of the serine/threonine-specific kinase [protein|search|RsbT] (see below).Modification
phosphorylation on Thr-171 and Thr-205 by [protein|search|RsbT] [Pubmed|21362065]Structure
[PDB|2BNL] (N-terminal domain), [PDB|3VY9] (complete stressosome)[SW|Interactions]
[protein|search|RsbX]-[protein|search|RsbR] [Pubmed|15466036][protein|search|RsbR]-[protein|search|RsbT] [Pubmed|21362065][protein|search|RsbR]-[protein|search|RsbS][protein|search|YtvA]-[protein|search|RsbR] [Pubmed|11157946]component of the [SW|stressosome]Expression and Regulation
Operon
''[protein|search|rsbR]-[protein|search|rsbS]-[protein|search|rsbT]-[protein|search|rsbU]-[protein|search|rsbV]-[protein|search|rsbW]-[protein|search|sigB]-[protein|search|rsbX]'' [Pubmed|8002610][SW|Sigma factor]
[protein|search|SigA] [Pubmed|8002610]Regulation
constitutively expressed [Pubmed|20019076]Additional information
belongs to the 100 [[most abundant proteins]] [PubMed|15378759]Labs working on this gene/protein
[SW|Bill Haldenwang], San Antonio, USA[SW|Chet Price], Davis, USA [http://foodscience.ucdavis.edu/price_lab/pricelab.html homepage][SW|Rick Lewis], Newcastle, UK [http://www.ncl.ac.uk/camb/staff/profile/r.lewis homepage]References
Reviews
19704888,16319496,20658979,23416074 Original Articles
8002610,8682769,8682789,17726680,10781545,15583165,8824586,10329124,17158665,9179850,8808936,15312768,11244072,15342582,15378759,12950928,15466036,9179850,8955331,18832644,17726680,17218307,20019076,21602359,23320651,21362065,20935101,22287516,22609918,24599254 
