tagC

possibly involved in polyglycerol phosphate teichoic acid biosynthesis

locus: BSU_35770

pI: 7.34

mw: 50.66 kDa

protein length: 442 aa

gene length: 1329 bp

function: biosynthesis of teichoic acid

product: unknown

essential: no

synonyms: dinC

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.1|Cell wall synthesis] → [category|SW 1.1.1.4|Biosynthesis of teichoic acid]
• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.1|Biosynthesis of cell wall components] → [category|SW 2.6.1.3|Biosynthesis of teichoic acid]

Gene

Coordinates: 3,683,438 3,684,766

The protein

Structure

• [PDB|5EFV] (from Staphylococcus aureus phage, corresponds to aa 14 ... 286, 32% identity) [pubmed|27282779]

[SW|Localization]

• cytoplasm (homogenous) [Pubmed|16479537]

Expression and Regulation

Operons

• genes: [gene|60344F56DEB167FA62C16E52E8238393CEE19312|tagC]
  description: [Pubmed|7934877]

  regulatory mechanism

  • [protein|D267AF38B0CF107042326E9B8F3DD3C9C85840E4|LexA]: repression, [PubMed|8226626,8969214], in [regulon|D267AF38B0CF107042326E9B8F3DD3C9C85840E4|LexA regulon]

  regulation

  • induced upon DNA damage ([protein|search|LexA]) [http://www.ncbi.nlm.nih.gov/sites/entrez/8226626,8969214 PubMed]

Biological materials

Mutant

• BKE35770 ([gene|60344F56DEB167FA62C16E52E8238393CEE19312|tagC]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE35770 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATAAATTTACCACCTCTAT, downstream forward: _UP4_TGATAATCAAATAGGCTGTA
• BKK35770 ([gene|60344F56DEB167FA62C16E52E8238393CEE19312|tagC]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK35770 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATAAATTTACCACCTCTAT, downstream forward: _UP4_TGATAATCAAATAGGCTGTA

References

• 8226626,8969214,9555905,7934877,16267290,16479537,27282779