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gerAB
nutrient receptor, [SW|germination] response to L-alanine, triggers premature [SW|germination] in response to morphological defects during [SW|sporulation]
function
germination response to L-alanine
product
nutrient receptor
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.4|Transporters/ other] → [category|SW 1.2.4.1|Amino acid transporters] → [category|SW 1.2.4.1.4|APC superfamily][category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.4|Germination] → [category|SW 4.2.4.1|Germinant receptors][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]Gene
Coordinates
3,392,199 3,393,296
Phenotypes of a mutant
suppresses the defects of [gene|40BCEB3648585961D22B71BBB4FB62EE4B3E360D|spoVV] mutant spores [pubmed|28605069]The protein
Catalyzed reaction/ biological activity
triggers premature [SW|germination] in response to morphological defects during [SW|sporulation] [pubmed|28605069]Protein family
[SW|amino acid-polyamine-organocation (APC) superfamily] (according to UniProt)[SW|Spore germination protein (SGP) (TC 2.A.3.9) family] (according to UniProt)Paralogous protein(s)
[protein|B14179D0EF5D3493E5CDB8E15378A5088B4FFD10|YndE], [protein|D1AFCB1BE693AB6B8461B7764B6641E6EB1404FA|GerKB], [protein|D70EC7C02BC79BED724489ABCB6356447F215B87|GerBB] [SW|Localization]
predicted to be an integral membrane protein with ten membrane-spanning helices [Pubmed|21378181]inner spore membrane [Pubmed|26731423]Expression and Regulation
Operons
genes
[gene|EEDE6A22E91992ABCA677CAB7917B7168C5CB868|gerAA]-[gene|5FF739B8C087207039BB6DC293EE77F59337ED0B|gerAB]-[gene|D937E26DF69D49B1341B37596AC6A8FBEEF8BA2E|gerAC]
description
[Pubmed|3110007]
sigma factors
[protein|5F24258282F3166B7696B9E9ABC1706E4D06C944|SigG]: sigma factor, [Pubmed|15699190], in [regulon|5F24258282F3166B7696B9E9ABC1706E4D06C944|SigG regulon][protein|CFF318EE6CACDEE763FBF96A2ABB46E944679AAA|SigF]: sigma factor, [Pubmed|16497325], in [regulon|CFF318EE6CACDEE763FBF96A2ABB46E944679AAA|SigF regulon]regulatory mechanism
[protein|01EF886D3D004EA9B22AC5E75D50FF07D8631E68|SpoVT]: repression, [Pubmed|8755877], in [regulon|01EF886D3D004EA9B22AC5E75D50FF07D8631E68|SpoVT regulon]regulation
expressed during sporulation in the forespore ([protein|search|SigF], [protein|search|SigG], [SW|SpoVT]) [Pubmed|16497325,15699190,8755877]additional information
1,100 molecules are present per spore [PubMed|23749970]view in new tabBiological materials
Mutant
BKE33060 ([gene|5FF739B8C087207039BB6DC293EE77F59337ED0B|gerAB]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE33060 BGSC], [Pubmed|28189581], upstream reverse: _UP1_AACAATAGAAATACCTTGAA, downstream forward: _UP4_CTCAAGAGGAGGATTACAACBKK33060 ([gene|5FF739B8C087207039BB6DC293EE77F59337ED0B|gerAB]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK33060 BGSC], [Pubmed|28189581], upstream reverse: _UP1_AACAATAGAAATACCTTGAA, downstream forward: _UP4_CTCAAGAGGAGGATTACAACReferences
Reviews
Original publications
3110007,17573930,12670969,2110996,15774895,16497325,16352818,8755877,21378181,21378197,21696470,22327596,23396907,24916603,22343299,16740944,26731423,28605069