iolR [2017-8-11 16:0:3]

transcriptional repressor of the iol operon, DeoR family

locus: BSU39770

pI: 6.33

mw: 28.25 kDa

protein length: 251 aa

gene length: 753 bp

function: regulation of myo-inositol catabolism

product: transcriptional repressor

essential: no

synonyms

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.16|Utilization of inositol]
• [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other]

Gene

Coordinates: 4,084,799 → 4,085,554

Phenotypes of a mutant

• inactivation of ''[gene|5F4ABBC8ECAD6F6C10EC39B2B0F0BC73F11522CE|iolR]'' reduces sporulation efficiency to 38% that of wild type cells [Pubmed|26735940]

The protein

Effectors of protein activity

• inducer: 2-deoxy-5-keto-D-gluconic acid-6-phosphate

Expression and Regulation

Operons

• genes: [gene|5F4ABBC8ECAD6F6C10EC39B2B0F0BC73F11522CE|iolR]-[gene|F1AFFACD36C75702B0BB8F0B4241A9688FB6253C|iolS]
  description: [Pubmed|9226270]

  sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|9226270], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]

  regulatory mechanism

  • [protein|5F4ABBC8ECAD6F6C10EC39B2B0F0BC73F11522CE|IolR]: repression, [Pubmed|9226270], in [regulon|5F4ABBC8ECAD6F6C10EC39B2B0F0BC73F11522CE|IolR regulon]

  regulation

  • induced by inositol ([protein|search|IolR]) [Pubmed|9226270]

Labs working on this gene/protein

• [SW|Yasutaro Fujita], University of Fukuyama, Japan
• [[Ken-ichi Yoshida]], Kobe University, Japan

References

• 18310071,9226270,9887260,9887260,18310071,26735940