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lutC
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lutC

lactate catabolic enzyme
Locus
BSU_34030
Isoelectric point
5.16
Molecular weight
26.13 kDa
Protein length
240 aa Sequence Blast
Gene length
723 bp Sequence Blast
Function
utilization of lactate
Product
unknown
Essential
no
Synonyms
yvbY

Genomic Context

      
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Categories containing this gene/protein

Gene

Coordinates
3,492,797 3,493,519

Phenotypes of a mutant

  • no growth with lactate as the single carbon source PubMed
  • The protein

    Catalyzed reaction/ biological activity

  • oxidation of lactate to pyruvate PubMed
  • Protein family

  • LutC/YkgG family (single member, according to UniProt)
  • Modification

  • phosphorylated on Arg-97 PubMed
  • Expression and Regulation

    Operons

    Description

    Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon
  • Regulatory mechanism

  • SinR: repression, PubMed, in SinR regulon
  • LutR: repression, in LutR regulon
  • Regulation

  • induction by lactate PubMed
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    Other regulations

  • FsrA: translation repression, PubMed
  • FbpB: translation inhibition, acts as RNA chaperone, increases interaction between FsrA and LutA-LutB-LutC RNAs
  • Biological materials

    Mutant

  • MGNA-A470 (yvbY::erm), available at the NBRP B. subtilis, Japan
  • BKE34030 (lutC::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_ATTCTGAATGGTTCCCTTCG, downstream forward: _UP4_TGAACTCAGGAAGCCCGGCA
  • BKK34030 (lutC::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_ATTCTGAATGGTTCCCTTCG, downstream forward: _UP4_TGAACTCAGGAAGCCCGGCA
  • Labs working on this gene/protein

  • Richard Losick, Harvard Univ., Cambridge, USA homepage
  • References

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