beta-ketoacyl-acyl carrier protein synthase II, involved in the control of membrane fluidity
function
fatty acid biosynthesis
product
beta-ketoacyl-acyl carrier protein synthase II
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.7|Membrane dynamics][category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.2|Biosynthesis of lipids] → [category|SW 2.4.2.1|Biosynthesis of fatty acids][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.2|Cell envelope stress proteins (controlled by SigM, V, W, X, Y)][category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes][SW|Categories] containing this gene/protein
[SW|membrane dynamics], [SW|biosynthesis of lipids], [SW|cell envelope stress proteins (controlled by SigM, V, W, X, Y)], [SW|essential genes]This gene is a member of the following [SW|regulons]
[SW|FapR regulon], [SW|SigW regulon]Gene
Phenotypes of a mutant
essential [Pubmed|12682299]The protein
Catalyzed reaction/ biological activity
(Z)-hexadec-11-enoyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = (Z)-3-oxooctadec-13-enoyl-[acyl-carrier-protein] + CO2 + [acyl-carrier-protein] (according to Swiss-Prot)[protein|search|SigW]-dependent expression of ''[protein|search|fabF]'' and the ''[protein|search|yuaF]-[protein|search|floT]-[protein|search|yuaI]'' operon result in reduced membrane fluidity [Pubmed|21542858,22178969]Protein family
beta-ketoacyl-ACP synthases family (according to Swiss-Prot)Structure
[PDB|4LS5] [Pubmed|24641521]Expression and Regulation
Operon
''[SW|fabHA]-[protein|search|fabF]'' [Pubmed|12737802][SW|Sigma factor]
''[SW|fabHA]'': [protein|search|SigA] [Pubmed|12737802]''[protein|search|fabF]'': [protein|search|SigW] [Pubmed|21542858]Regulation
''[SW|fabHA]'': expressed when the cells experience a lack of malonyl-CoA ([protein|search|FapR]) [Pubmed|12737802]''[SW|fabHA]'': induced upon fatty acid biosynthesis inhibition [Pubmed|21383089]''[protein|search|fabF]'': induced by alkaline shock and by polymyxin B, vancomycin, cephalosporin C, D-cycloserine, and triton X-100 ([protein|search|SigW]) [Pubmed|21542858]Regulatory mechanism
[protein|search|FapR]: transcription repression [Pubmed|12737802]References
Reviews
Original Publications
18384517,12837788,12737802,12682299,21383089,24641521,21542858,22178969 
