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pyrF [Mon Aug 31 2015 13:54:13 GMT+0200 (CEST)]
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pyrF [Mon Aug 31 2015 13:54:13 GMT+0200 (CEST)]

orotidine 5-phosphate decarboxylase
locus
BSU15550
pI
5.84
mw
25.00 kDa
function
pyrimidine biosynthesis
product
orotidine-5-phosphate decarboxylase
essential
no
ec
4.1.1.23
synonyms

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.2|Biosynthesis/ acquisition of nucleotides] → [category|SW 2.5.2.4|Biosynthesis/ acquisition of pyrimidine nucleotides]
  • [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.9|Newly identified competence genes]
  • [SW|Categories] containing this gene/protein

  • [SW|biosynthesis/ acquisition of nucleotides]
  • This gene is a member of the following [SW|regulons]

  • [SW|PyrR regulon]
  • The protein

    Catalyzed reaction/ biological activity

  • Orotidine 5'-phosphate = UMP + CO2 (according to Swiss-Prot)
  • Protein family

  • Type 1 subfamily (according to Swiss-Prot)
  • Structure

  • [PDB|1DBT]
  • Expression and Regulation

    Operon

  • ''[protein|search|pyrR]-[protein|search|pyrP]-[protein|search|pyrB]-[protein|search|pyrC]-[SW|pyrAA]-[SW|pyrAB]-[protein|search|pyrK]-[protein|search|pyrD]-[protein|search|pyrF]-[protein|search|pyrE]'' [Pubmed|8206849]
  • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|1709162]
  • Regulation

  • induced in the absence of uridine nucleotides ([protein|search|PyrR]) [Pubmed|8206849]
  • Regulatory mechanism

  • [protein|search|PyrR]: [SW|RNA switch], transcription termination/ antitermination (in the presence of uridine nucleotides: termination, in their absence: antitermination) [Pubmed|8955403]
  • References

  • 8206849,1709162,25326311