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dnaC [Mon Jan 18 2016 17:10:40 GMT+0100 (CET)]
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dnaC [Mon Jan 18 2016 17:10:40 GMT+0100 (CET)]

replicative DNA helicase, part of the replisome
locus
BSU40440
pI
4.00
mw
50.00 kDa
function
DNA replication
product
replicative DNA helicase
essential
yes
ec
3.6.4.12
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.1|DNA replication]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

    • [SW|Categories] containing this gene/protein

  • [SW|DNA replication], [SW|essential genes]

    • Gene

    Coordinates on the chromosome (coding sequence)
    4,157,471 -> 4,158,835

    Phenotypes of a mutant

  • essential [Pubmed|12682299]

    • The protein

    Catalyzed reaction/ biological activity

  • stimulates [protein|search|DnaG] primase activity [Pubmed|23563155]

    • Protein family

  • DnaB subfamily (according to Swiss-Prot)

    • Structure

  • [PDB|2R6A] (Geobacillus stearothermophilus), [PDB|2R6C], [PDB|2R6D], [PDB|2R6E]
  • [PDB|4M4W] (the [protein|search|DnaC]-[protein|search|DnaI]-[protein|search|DnaG] complex) [Pubmed|24048025]

    • [SW|Localization]

  • Cytoplasm (Homogeneous) [Pubmed|16479537]

    • [SW|Interactions]

  • [protein|search|DnaB]-[protein|search|DnaC] [Pubmed|11250911]
  • [protein|search|DnaI]-[protein|search|DnaC] [Pubmed|10844689]
  • part of the [SW|replisome]: [protein|search|PolC]-[protein|search|HolA]-[protein|search|HolB]-[protein|search|DnaX]-[protein|search|DnaN]-[protein|search|DnaG]-[protein|search|DnaC]-[protein|search|DnaI]-[protein|search|DnaD]-[protein|search|SsbA]-[protein|search|DnaE]-[protein|search|PriA]-[protein|search|DnaB] [Pubmed|20122408]
  • [protein|search|YqaM]-[protein|search|DnaC] [Pubmed|12060778]
  • part of the [SW|primosome]: [protein|search|DnaA]-[protein|search|DnaG]-[protein|search|DnaC]-[protein|search|DnaI]-[protein|search|DnaD]-[protein|search|DnaB] [Pubmed|22797751]
  • [protein|search|DnaX]-[protein|search|DnaC] [Pubmed|23525462]
  • [protein|search|DnaE]-[protein|search|DnaC] [Pubmed|23563155]
  • [protein|search|DnaG]-[protein|search|DnaC] [Pubmed|23563155]

    • Expression and Regulation

    Operon

  • ''dnaC'' (according to [http://dbtbs.hgc.jp/COG/prom/dnaC.html DBTBS])

    • Biological materials

    two-hybrid system

  • B. pertussis adenylate cyclase-based bacterial two hybrid system ([SW|BACTH]), available in [SW|Fabian Commichau]'s lab

    • References

    Reviews

  • 22797751

    • Original publications

  • 10844689,12718886,11250911,20122408,16479537,10844689,19744498,19968790,12060778,23525462,23563155,24048025