cadA [Tue Dec 13 2016 11:16:36 GMT+0100 (CET)]

cadmium transporting ATPase, resistance to cadmium

locus: BSU33490

pI: 6.00

mw: 75.00 kDa

function: cadmium export

product: cadmium transporting ATPase

essential: no

ec: 3.6.3.3

synonyms: yvgW

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.4|Transporters/ other] → [category|SW 1.2.4.5|Metal ion transporter]
• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.11|Resistance against toxic metals]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

[SW|Categories] containing this gene/protein

• [SW|transporters/ other], [SW|resistance against toxic metals], [SW|membrane proteins]

This gene is a member of the following [SW|regulons]

• [SW|CzrA regulon]

Gene

Coordinates on the chromosome (coding sequence): 3,438,853 -> 3,440,952

The protein

Catalyzed reaction/ biological activity

• ATP + H₂O + Cd²⁺(In) = ADP + phosphate + Cd²⁺(Out) (according to Swiss-Prot)

Protein family

• Type IB subfamily (according to Swiss-Prot)

Structure

• [PDB|4BBJ] (CopA from ''Legionella pneumophila'', 32% identity, 67% similarity) [Pubmed|24317491]

[SW|Localization]

• cell membrane (according to Swiss-Prot)

Expression and Regulation

Operon

• ''cadA'' [Pubmed|12779235]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|12779235]

Regulation

• induced by toxic metal ions (Zn(II), Cd(II), Co(II), Ni(II) and Cu(II)) ([protein|search|CzrA]) [Pubmed|12779235,15948947]

Regulatory mechanism

• [protein|search|CzrA]: transcription repression [Pubmed|15948947]

Labs working on this gene/protein

• [SW|John Helmann], Cornell University, USA [http://www.micro.cornell.edu/research/labs/helmann-lab/index.cfm Homepage]

References

• 15948947,12779235,24317491,11934502,25213752