Spx-dependent FMN-containing NADPH-linked nitro/flavin reductase, stress protein
product
FMN-containing NADPH-linked nitro/flavin reductase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.1|Electron transport and ATP synthesis] → [category|SW 2.1.3|Electron transport/ other][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.8|Resistance against oxidative and electrophile stress][SW|Categories] containing this gene/protein
[SW|electron transport/ other], [SW|resistance against oxidative and electrophile stress]This gene is a member of the following [SW|regulons]
[SW|SigD regulon], [SW|Spo0A regulon], [SW|Spx regulon]Gene
Coordinates on the chromosome (coding sequence)
3,911,477 -> 3,912,226
The protein
Catalyzed reaction/ biological activity
possesses an NADH oxidase activity that leads to high concentrations of oxygen peroxide and an NAD( ) degrading activity leading to free nicotinamide [Pubmed|20727352]Protein family
flavin oxidoreductase frp family (according to Swiss-Prot)[SW|Cofactors]
FMN or FAD [Pubmed|21635694]Structure
[PDB|3N2S] [Pubmed|20727352]Expression and Regulation
Operon
''[protein|search|nfrA]-[protein|search|ywcH]'' [Pubmed|10913069][SW|Sigma factor]
[protein|search|SigA] [Pubmed|10913069], [protein|search|SigD] [Pubmed|9535080]Regulation
repressed under conditions that trigger sporulation ([SW|Spo0A]) [Pubmed|14651647]Regulatory mechanism
[SW|Spo0A]: transcription repression [Pubmed|14651647][protein|search|Spx]: transcription activation [Pubmed|12642660,19575568]References
9535080,16847875,10913069,12642660,14651647,20727352,9836433,24847778 
