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parA [Tue Oct 25 2016 12:40:54 GMT+0200 (CEST)]
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parA [Tue Oct 25 2016 12:40:54 GMT+0200 (CEST)]

ATPase, centromere-like function involved in forespore chromosome partitioning / negative regulation of sporulation initiation
locus
BSU40970
pI
4.00
mw
27.00 kDa
function
forespore chromosome partitioning /
negative regulation of sporulation initiation
product
negative regulator of sporulation initiation
essential
no
synonyms
soj, spo0JA

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.3|DNA condensation/ segregation]
  • [category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.3|Sporulation/ other]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]
  • [SW|Categories] containing this gene/protein

  • [SW|DNA condensation/ segregation], [SW|sporulation/ other], [SW|membrane proteins]
  • This gene is a member of the following [SW|regulons]

  • [SW|Spo0A regulon]
  • Gene

    Coordinates on the chromosome (coding sequence)
    4,206,397 -> 4,207,158

    The protein

    Catalyzed reaction/ biological activity

  • regulates [SW|DNA replication] initiation by either inhibiting or activating the [SW|DNA replication] initiator protein [protein|search|DnaA] [Pubmed|21235642]; regulation of ''Spo0A'' expression [Pubmed|10852876]
  • Protein family

  • parA family (according to Swiss-Prot)
  • Effectors of protein activity

  • [protein|search|ParB] inhibits [protein|search|ParA] dimerization and concomitant DNA-binding activity by stimulating [protein|search|ParA] ATPase activity [Pubmed|21235642]
  • [SW|Localization]

  • polar/ septal at the cell membrane [Pubmed|20566861]
  • polar localization depends on the proton motive force [Pubmed|20566861]
  • [SW|Interactions]

  • [protein|search|ParA]-[protein|search|ParB] [Pubmed|21235642]
  • [protein|search|ParA]-[protein|search|DnaA] [Pubmed|22286949]
  • Expression and Regulation

    Operon

  • ''[protein|search|parA]-[protein|search|parB]'' [Pubmed|22383849]
  • Regulation

  • repressed under conditions that trigger sporulation ([SW|Spo0A]) [Pubmed|14651647]
  • Regulatory mechanism

  • [SW|Spo0A]: transcription repression [Pubmed|14651647]
  • Labs working on this gene/protein

  • [SW|Heath Murray], Centre for Bacterial Cell Biology, Newcastle, UK [http://www.ncl.ac.uk/camb/staff/profile/heath.murray homepage]
  • References

    Reviews

  • 20157337,22934648,26286503,26706151
  • Original publications

  • 15659156,11532141,19450516,18854156,10619015,8866474,12492861,9701805,12950914,14651647,19450516,20566861,21235642,10852876,14563866,26253537,22286949,21911367,27059541,27489185